Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS1 | P29475 | 6/20 | 0.51 |
| ▸ | STK17B | O94768 | 2/20 | 0.41 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.41 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.40 |
| ▸ | NEK2 | P51955 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | PDE4A | P27815 | 1/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.38 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.38 |
| ▸ | DHODH | Q02127 | 1/20 | 0.37 |
| ▸ | AMY1A | P0DUB6 | 1/20 | 0.36 |
| ▸ | MAP3K11 | Q16584 | 1/20 | 0.36 |
| ▸ | GAK | O14976 | 1/20 | 0.36 |
| ▸ | CCNC | P24863 | 1/20 | 0.36 |
| ▸ | CDK8 | P49336 | 1/20 | 0.36 |
| ▸ | ATR | Q13535 | 1/20 | 0.36 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5457330 | 0.91 | NOS1 (0.53) | NOS1STK17BSTK17ACHEK1NEK2 | |
| SCHEMBL5463628 | 0.88 | NOS1 (0.51) | NOS1STK17BSTK17ANEK2PDE4A | |
| SCHEMBL5470249 | 0.86 | NOS1 (0.51) | NOS1STK17BNEK2DHODH | |
| SCHEMBL5463636 | 0.86 | NOS1 (0.51) | NOS1STK17BSTK17ACHEK1NEK2 | |
| SCHEMBL6064705 | 0.86 | NOS1 (0.60) | NOS1STK17BSTK17ANEK2PDE4A | |
| SCHEMBL5461836 | 0.85 | NOS1 (0.51) | NOS1STK17BSTK17ANEK2PDE4A | |
| SCHEMBL5466005 | 0.84 | NOS1 (0.54) | NOS1STK17BSTK17ACHEK1NEK2 | |
| SCHEMBL5464734 | 0.84 | NOS1 (0.57) | NOS1STK17BSTK17ANEK2PDE4A | |
| SCHEMBL5469822 | 0.84 | NOS1 (0.62) | NOS1STK17BSTK17ANEK2PDE4A | |
| SCHEMBL5461552 | 0.83 | NOS1 (0.53) | NOS1STK17BSTK17ACHEK1NEK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1673092-B1 | HETEROCYCLE-SUBSTITUTED PTERIDINE DERIVATIVES AND THEIR USE IN THERAPY | 4 AZA IP NV (BE) | 2007-08-15 | — | — | EP | disclosed |