Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 3/20 | 0.49 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.49 |
| ▸ | F2 | P00734 | 1/20 | 0.49 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.49 |
| ▸ | DPP4 | P27487 | 2/20 | 0.48 |
| ▸ | DPP8 | Q6V1X1 | 2/20 | 0.48 |
| ▸ | DPP9 | Q86TI2 | 2/20 | 0.48 |
| ▸ | DPP7 | Q9UHL4 | 2/20 | 0.48 |
| ▸ | FAP | Q12884 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5597620 | 1.00 | OPRM1 (0.49) | OPRM1OPRD1F2OPRK1DPP4 | |
| SCHEMBL7418654 | 1.00 | OPRM1 (0.49) | OPRM1OPRD1F2OPRK1DPP4 | |
| SCHEMBL2192304 | 1.00 | OPRM1 (0.49) | OPRM1OPRD1F2OPRK1DPP4 | |
| SCHEMBL2182404 | 0.97 | F2 (0.47) | OPRM1OPRD1F2OPRK1DPP4 | |
| SCHEMBL7207928 | 0.90 | OPRM1 (0.51) | OPRM1F2OPRK1 | |
| SCHEMBL2193283 | 0.89 | OPRM1 (0.48) | OPRM1OPRD1OPRK1 | |
| SCHEMBL9280512 | 0.89 | XIAP (0.48) | OPRM1F2OPRK1 | |
| SCHEMBL6497247 | 0.88 | F2 (0.57) | OPRM1OPRD1F2OPRK1 | |
| SCHEMBL2778546 | 0.88 | F2 (0.57) | OPRM1OPRD1F2OPRK1 | |
| SCHEMBL6850160 | 0.88 | F2 (0.57) | OPRM1OPRD1F2OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0863768-B1 | Covalent heparin-protein conjugates comprising an alpha-carbonyl amine bond and methods of obtaining them | UNIV MCMASTER (CA) | 2007-01-03 | — | — | EP | disclosed |
| US-7045585-B2 | Methods of coating a device using anti-thrombin heparin | HAMILTON CIVIC HOSPITAL RESEARCH DEVELOPMENT INC. (CA) | 2006-05-16 | — | — | US | disclosed |
| US-20030124705-A1 | Glycosaminoglycan-antithrombin III/heparin cofactor II conjugates | MCMASTER UNIVERSITY (CA) | 2003-07-03 | — | — | US | disclosed |
| US-20030113314-A1 | Heparin directly linked to antithrombin III by a covalent linkage comprises atleast one primary amino group, via a linkage between primary amino group of antithrombin III and terminal residue of heparin; anticoagulant; prosthetics | HAMILTON CIVIC HOSPITALS RES DEV., INC. (CA) | 2003-06-19 | — | — | US | disclosed |
| US-20030100487-A1 | For prophylaxis and therapy of thrombogenesis in lung airways, such as found in infant and adult respiratory distress syndrome | HAMILTON CIVIC HOSPITALS RES DEV., INC. (CA) | 2003-05-29 | — | — | US | disclosed |
| US-6562781-B1 | Covalent conjugate composition comprising glycosaminoglycans linked by covalent linkages to a species comprising at least one primary amino group | HAMILTON CIVIC HOSPITALS RESEARCH DEVELOPMENT INC. (CA) | 2003-05-13 | — | — | US | disclosed |
| US-6491965-B1 | COVALENT LINKAGES COMPRISING AN ALPHA CARBONYL AMINE FORMED BY A AMADORI REARRANGEMENT OF AN IMINE RESULTING FROM REACTION BETWEEN SAID AMINO GROUP OF ANTITHROMBIN AND TERMINAL ALDOSE RESIDUE OF HEPARIN | HAMILTON CIVIC HOSPITALS RESEARCH DEVELOPMENT, INC. (CA) | 2002-12-10 | — | — | US | disclosed |
| EP-0863768-A2 | GLYCOSAMINOGLYCAN-ANTITHROMBIN III/HEPARIN COFACTOR II CONJUGATES | HAMILTON CIVIC HOSPITALS RESEARCH DEVELOPMENT, INC. (CA) | 1998-09-16 | — | — | EP | disclosed |
| WO-1997019701-A2 | GLYCOSAMINOGLYCAN-ANTITHROMBIN III/HEPARIN COFACTOR II CONJUGATES | HAMILTON CIVIC HOSPITALS RESEARCH DEVELOPMENT, INC. (CA) | 1997-06-05 | — | — | WO | disclosed |