SCHEMBL5597859

SCHEMBL5597859

N#Cc1c(C(F)(F)F)cc(-c2cc(C(N)=O)ccc2-c2ccccc2)n(Cc2ccc(F)cc2F)c1=O

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RXRA P19793 3/20 0.61
NR1H2 P55055 3/20 0.61
NR1H3 Q13133 3/20 0.61
MAPK14 Q16539 3/20 0.35
GNRHR P30968 1/20 0.35
RIPK3 Q9Y572 1/20 0.35
ALDH1A1 P00352 4/20 0.35
POLB P06746 1/20 0.35
KMT2A Q03164 1/20 0.35
PTGER1 P34995 1/20 0.34
TNKS O95271 2/20 0.34
TNKS2 Q9H2K2 2/20 0.34
KDM4E B2RXH2 3/20 0.34
GLA P06280 1/20 0.34
GAA P10253 1/20 0.34
HPGD P15428 1/20 0.34
ADORA2A P29274 1/20 0.34
ADORA1 P30542 1/20 0.34
KDM1A O60341 1/20 0.33
MAPT P10636 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5597991 0.90 RXRA (0.59) RXRANR1H2NR1H3MAPK14GNRHR
SCHEMBL5610672 0.87 RXRA (0.69) RXRANR1H2NR1H3MAPK14ALDH1A1
SCHEMBL5806479 0.86 RXRA (0.45) RXRANR1H2NR1H3ALDH1A1POLB
SCHEMBL2386543 0.85 RXRA (0.62) RXRANR1H2NR1H3MAPK14PTGER1
SCHEMBL2389509 0.85 RXRA (0.63) RXRANR1H2NR1H3MAPK14ALDH1A1
SCHEMBL5793671 0.84 RXRA (0.61) RXRANR1H2NR1H3MAPK14GNRHR
SCHEMBL2262731 0.84 RXRA (0.83) RXRANR1H2NR1H3MAPK14GNRHR
SCHEMBL5610677 0.82 RXRA (0.65) RXRANR1H2NR1H3MAPK14GNRHR
SCHEMBL14214400 0.82 RXRA (0.84) RXRANR1H2NR1H3MAPK14GNRHR
SCHEMBL5816753 0.81 RXRA (0.64) RXRANR1H2NR1H3MAPK14GNRHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1773337-A2 MODULATORS OF NUCLEAR RECEPTORS Exelixis, Inc. (US) 2007-04-18 EP disclosed
WO-2006025979-A2 MODULATORS OF NUCLEAR RECEPTORS EXELIXIS, INC. (US) 2006-03-09 WO disclosed