Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 3/20 | 0.61 |
| ▸ | NR1H2 | P55055 | 3/20 | 0.61 |
| ▸ | NR1H3 | Q13133 | 3/20 | 0.61 |
| ▸ | GNRHR | P30968 | 6/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.39 |
| ▸ | PARP1 | P09874 | 1/20 | 0.36 |
| ▸ | AURKA | O14965 | 1/20 | 0.35 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.35 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.35 |
| ▸ | RIPK3 | Q9Y572 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | TNKS | O95271 | 1/20 | 0.34 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5598178 | 0.90 | RXRA (0.58) | RXRANR1H2NR1H3GNRHRMAPK14 | |
| SCHEMBL5597884 | 0.89 | RXRA (0.57) | RXRANR1H2NR1H3GNRHRALDH1A1 | |
| SCHEMBL5816750 | 0.88 | RXRA (0.61) | RXRANR1H2NR1H3GNRHRMAPK14 | |
| SCHEMBL5796476 | 0.86 | RXRA (0.44) | RXRANR1H2NR1H3GNRHRPARP1 | |
| SCHEMBL5597859 | 0.84 | RXRA (0.61) | RXRANR1H2NR1H3GNRHRMAPK14 | |
| SCHEMBL2262731 | 0.83 | RXRA (0.83) | RXRANR1H2NR1H3GNRHRMAPK14 | |
| SCHEMBL14214340 | 0.81 | RXRA (0.75) | RXRANR1H2NR1H3GNRHRMAPK14 | |
| SCHEMBL2386543 | 0.81 | RXRA (0.62) | RXRANR1H2NR1H3MAPK14TNKS | |
| SCHEMBL14214400 | 0.81 | RXRA (0.84) | RXRANR1H2NR1H3GNRHRMAPK14 | |
| SCHEMBL2389509 | 0.81 | RXRA (0.63) | RXRANR1H2NR1H3MAPK14ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006025979-A9 | MODULATORS OF NUCLEAR RECEPTORS | EXELIXIS INC (US) | 2006-04-20 | — | — | WO | disclosed |