SCHEMBL5597907

SCHEMBL5597907

Nc1cccc(NC(=O)Nc2cc(C3CC3)n[nH]2)c1

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
DDX3X O00571 2/20 0.57
ALDH1A1 P00352 2/20 0.44
KCNJ6 P48051 8/20 0.43
KCNJ3 P48549 8/20 0.43
KCNJ5 P48544 5/20 0.43
MAPT P10636 2/20 0.40
MEN1 O00255 1/20 0.40
LMNA P02545 1/20 0.40
HTT P42858 1/20 0.40
KMT2A Q03164 1/20 0.40
KDR P35968 2/20 0.39
MAPK13 O15264 1/20 0.39
MAPK12 P53778 1/20 0.39
MAPK11 Q15759 1/20 0.39
MAPK14 Q16539 1/20 0.39
VHL P40337 1/20 0.39
KIT P10721 1/20 0.39
FLT3 P36888 1/20 0.39
PRKCI P41743 1/20 0.39
ULK1 O75385 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5597514 0.88 TRPV1 (0.44) DDX3XALDH1A1KCNJ6KCNJ3KCNJ5
SCHEMBL5597709 0.87 RAB9A (0.50) DDX3XKCNJ6KCNJ3KCNJ5MAPT
SCHEMBL5597942 0.87 TP53 (0.47) ALDH1A1KCNJ6KCNJ3KCNJ5MAPT
SCHEMBL5597878 0.85 MEN1 (0.53) ALDH1A1MAPTMEN1HTTKMT2A
SCHEMBL5597764 0.85 NPC1 (0.53) KCNJ6KCNJ3KCNJ5MEN1LMNA
SCHEMBL7050959 0.84 HDAC6 (0.44) KCNJ6KCNJ3KCNJ5MEN1KMT2A
SCHEMBL5597634 0.84 KCNJ6 (0.41) DDX3XALDH1A1KCNJ6KCNJ3KCNJ5
SCHEMBL5597510 0.84 KCNJ6 (0.41) DDX3XALDH1A1KCNJ6KCNJ3KCNJ5
SCHEMBL5597681 0.83 TP53 (0.54) ALDH1A1MAPTMEN1LMNAHTT
SCHEMBL5597880 0.83 RXFP1 (0.44) ALDH1A1KCNJ6KCNJ3KCNJ5MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1202734-B1 3(5)-UREIDO-PYRAZOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS ANTITUMOR AGENTS PFIZER ITALIA SRL (IT) 2007-05-02 EP claimed
EP-1202734-A4 3(5)-UREIDO-PYRAZOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS ANTITUMOR AGENTS PHARMACIA ITALIA SPA (IT) 2004-09-01 EP claimed
JP-2003507328-A 2003-02-25 JP claimed
US-6387900-B1 ANTICANCER AGENTS PHARMACIA & UPJOHN S.P.A. (IT) 2002-05-14 US claimed
EP-1202734-A1 3(5)-UREIDO-PYRAZOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS ANTITUMOR AGENTS Pharmacia Italia S.p.A. (IT) 2002-05-08 EP claimed
WO-2001012188-A1 3(5)-UREIDO-PYRAZOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS ANTITUMOR AGENTS PHARMACIA & UPJOHN S.P.A. (IT) 2001-02-22 WO claimed
WO-2018089561-A1 COMPOSITIONS AND METHODS OF USE OF PHORBOL ESTERS IN THE TREATMENT OF PARKINSON'S DISEASE RICH PHARMACEUTICALS, INC. (US) 2018-05-17 WO disclosed
EP-1202734-A4 3(5)-UREIDO-PYRAZOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS ANTITUMOR AGENTS PHARMACIA ITALIA SPA (IT) 2004-09-01 EP disclosed
US-20030009776-A1 Mice with combined disruption of Gpx1 and Gpx2 genes have growth retardation, hypothermia, and colitis and provide a mouse model for cancer CITY OF HOPE 2003-01-09 US disclosed
US-6387900-B1 ANTICANCER AGENTS PHARMACIA & UPJOHN S.P.A. (IT) 2002-05-14 US disclosed
EP-1202734-A1 3(5)-UREIDO-PYRAZOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS ANTITUMOR AGENTS Pharmacia Italia S.p.A. (IT) 2002-05-08 EP disclosed
WO-2001012188-A1 3(5)-UREIDO-PYRAZOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS ANTITUMOR AGENTS PHARMACIA & UPJOHN S.P.A. (IT) 2001-02-22 WO disclosed