Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.74 |
| ▸ | RAB9A | P51151 | 5/20 | 0.74 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.74 |
| ▸ | MEN1 | O00255 | 2/20 | 0.74 |
| ▸ | LMNA | P02545 | 1/20 | 0.74 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.74 |
| ▸ | CRHBP | P24387 | 1/20 | 0.74 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.74 |
| ▸ | HTT | P42858 | 1/20 | 0.68 |
| ▸ | MAOB | P27338 | 5/20 | 0.65 |
| ▸ | MAOA | P21397 | 3/20 | 0.60 |
| ▸ | POLB | P06746 | 3/20 | 0.60 |
| ▸ | NPC1 | O15118 | 2/20 | 0.60 |
| ▸ | CAPN1 | P07384 | 2/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.60 |
| ▸ | ALPL | P05186 | 1/20 | 0.60 |
| ▸ | ALPI | P09923 | 1/20 | 0.60 |
| ▸ | ALPG | P10696 | 1/20 | 0.60 |
| ▸ | CTSB | P07858 | 1/20 | 0.60 |
| ▸ | HPGD | P15428 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL979280 | 0.86 | MAPT (0.79) | MAPTRAB9AKMT2AMEN1LMNA | |
| SCHEMBL2053346 | 0.86 | MAPT (0.79) | MAPTRAB9AKMT2AMEN1LMNA | |
| SCHEMBL15155060 | 0.85 | MAPT (0.72) | MAPTRAB9AKMT2AMEN1LMNA | |
| SCHEMBL13721173 | 0.85 | MAPT (1.00) | MAPTRAB9AKMT2AMEN1LMNA | |
| SCHEMBL15155058 | 0.85 | MAPT (0.72) | MAPTRAB9AKMT2AMEN1LMNA | |
| SCHEMBL3096975 | 0.85 | MAPT (0.77) | MAPTRAB9AKMT2AMEN1LMNA | |
| SCHEMBL3096978 | 0.85 | MAPT (0.77) | MAPTRAB9AKMT2AMEN1LMNA | |
| SCHEMBL1321556 | 0.84 | MAPT (0.75) | MAPTRAB9AKMT2AMEN1LMNA | |
| SCHEMBL1321557 | 0.84 | MAPT (0.75) | MAPTRAB9AKMT2AMEN1LMNA | |
| SCHEMBL18906024 | 0.84 | MAPT (0.70) | MAPTRAB9AKMT2AMEN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1815860-A2 | Phosphate transport inhibitors | GENZYME CORPORATION (US) | 2007-08-08 | — | — | EP | disclosed |
| US-20070021509-A1 | Phosphate transport inhibitors | JOZEFIAK THOMAS H | 2007-01-25 | — | — | US | disclosed |
| US-7119120-B2 | Phosphate transport inhibitors | GENZYME CORPORATION (US) | 2006-10-10 | — | — | US | disclosed |
| EP-1465638-A2 | PHOSPHATE TRANSPORT INHIBITORS | GENZYME CORPORATION (US) | 2004-10-13 | — | — | EP | disclosed |
| US-20040019113-A1 | Phosphate transport inhibitors | GELTEX PHARMACEUTICALS, INC. | 2004-01-29 | — | — | US | disclosed |
| WO-2003057225-A2 | PHOSPHATE TRANSPORT INHIBITORS | GENZYME CORPORATION (US) | 2003-07-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040019113-A1 | Phosphate transport inhibitors | SLC34A1, SLC34A2, SLC20A1 | MAPT 3148/4885RAB9A 2346/4885KMT2A 4536/4885 |
| US-20070021509-A1 | Phosphate transport inhibitors | SLC34A2, SLC34A1, SLC20A1 | MAPT 3058/4885RAB9A 2409/4885KMT2A 4634/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.