Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 3/20 | 0.58 |
| ▸ | NR1H2 | P55055 | 3/20 | 0.58 |
| ▸ | NR1H3 | Q13133 | 3/20 | 0.58 |
| ▸ | GNRHR | P30968 | 5/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | KCNK3 | O14649 | 2/20 | 0.34 |
| ▸ | RIPK3 | Q9Y572 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | TACR1 | P25103 | 1/20 | 0.33 |
| ▸ | USP19 | O94966 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5793671 | 0.90 | RXRA (0.61) | RXRANR1H2NR1H3GNRHRKMT2A | |
| SCHEMBL5597884 | 0.88 | RXRA (0.57) | RXRANR1H2NR1H3GNRHRKMT2A | |
| SCHEMBL5792823 | 0.88 | RXRA (0.43) | RXRANR1H2NR1H3GNRHRKMT2A | |
| SCHEMBL5816750 | 0.85 | RXRA (0.61) | RXRANR1H2NR1H3GNRHRKMT2A | |
| SCHEMBL5597991 | 0.85 | RXRA (0.59) | RXRANR1H2NR1H3GNRHRKMT2A | |
| SCHEMBL2391077 | 0.82 | RXRA (0.59) | RXRANR1H2NR1H3MAPK14KCNK3 | |
| SCHEMBL2389383 | 0.82 | RXRA (0.61) | RXRANR1H2NR1H3MAPK14KCNK3 | |
| SCHEMBL2262731 | 0.81 | RXRA (0.83) | RXRANR1H2NR1H3GNRHRKMT2A | |
| SCHEMBL14214340 | 0.80 | RXRA (0.75) | RXRANR1H2NR1H3GNRHRKMT2A | |
| SCHEMBL14214400 | 0.79 | RXRA (0.84) | RXRANR1H2NR1H3GNRHRKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1773337-A2 | MODULATORS OF NUCLEAR RECEPTORS | Exelixis, Inc. (US) | 2007-04-18 | — | — | EP | claimed |
| WO-2006025979-A2 | MODULATORS OF NUCLEAR RECEPTORS | EXELIXIS, INC. (US) | 2006-03-09 | — | — | WO | claimed |