Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 4/20 | 0.49 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.45 |
| ▸ | GAA | P10253 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.43 |
| ▸ | FHIT | P49789 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5596728 | 0.79 | NPSR1 (0.38) | HPGDLMNAALDH1A1HTTKDM4E | |
| SCHEMBL1989883 | 0.77 | LMNA (0.56) | HPGDLMNAALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL7005884 | 0.76 | ALDH1A1 (0.50) | HPGDALDH1A1HTTKDM4ERECQL | |
| SCHEMBL7480180 | 0.75 | HPGD (0.51) | HPGDALDH1A1HTTKDM4ERECQL | |
| SCHEMBL11648197 | 0.72 | CYP1A2 (0.66) | HPGDLMNAALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL3550531 | 0.71 | HPGD (0.56) | HPGDLMNAALDH1A1HTTKDM4E | |
| SCHEMBL8205190 | 0.71 | HPGD (0.59) | HPGDLMNAALDH1A1HTTKDM4E | |
| SCHEMBL9898080 | 0.70 | HPGD (0.69) | HPGDLMNAALDH1A1HTTKDM4E | |
| SCHEMBL6825138 | 0.70 | HPGD (0.50) | HPGDLMNAALDH1A1HTTKDM4E | |
| SCHEMBL24229974 | 0.69 | KDM4E (0.46) | HPGDLMNAALDH1A1HTTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1539763-A4 | AZAINDOLE KINASE INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2007-08-01 | — | — | EP | disclosed |
| EP-1539763-A1 | AZAINDOLE KINASE INHIBITORS | Bristol-Myers Squibb Company (US) | 2005-06-15 | — | — | EP | disclosed |
| WO-2004009601-A1 | AZAINDOLE KINASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2004-01-29 | — | — | WO | disclosed |