Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNF | P01375 | 1/20 | 0.60 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.60 |
| ▸ | RAB9A | P51151 | 6/20 | 0.42 |
| ▸ | NPC1 | O15118 | 5/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
| ▸ | TNKS | O95271 | 1/20 | 0.36 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.36 |
| ▸ | APP | P05067 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5591719 | 0.85 | TNF (0.42) | TNFNOD1RAB9ANPC1KDM4E | |
| SCHEMBL5540904 | 0.81 | KDM4E (0.42) | TNFNOD1RAB9ANPC1KDM4E | |
| SCHEMBL10495624 | 0.80 | APP (0.57) | RAB9ANPC1KDM4EMAPTALDH1A1 | |
| SCHEMBL5547745 | 0.78 | KDM4E (0.56) | RAB9ANPC1KDM4EMAPTALDH1A1 | |
| SCHEMBL20597734 | 0.76 | CASR (0.40) | TNFNOD1ALDH1A1L3MBTL1LMNA | |
| SCHEMBL13118015 | 0.75 | TNF (1.00) | TNFNOD1RAB9ANPC1KDM4E | |
| SCHEMBL5591820 | 0.73 | ALDH1A1 (0.47) | RAB9ANPC1KDM4EHDAC6MAPT | |
| SCHEMBL5591755 | 0.72 | PIK3CD (0.42) | RAB9ANPC1MEN1KMT2A | |
| SCHEMBL15746019 | 0.72 | TNF (0.61) | TNFNOD1RAB9ANPC1KDM4E | |
| SCHEMBL25027881 | 0.71 | TNF (0.71) | TNFNOD1RAB9ANPC1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007076104-A1 | VANILLOID RECEPTOR LIGANDS AND THEIR USE IN TREATMENTS | AMGEN INC. (US) | 2007-07-05 | — | — | WO | disclosed |