Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | JAK2 | O60674 | 6/20 | 0.53 |
| ▸ | JAK1 | P23458 | 6/20 | 0.53 |
| ▸ | TYK2 | P29597 | 6/20 | 0.53 |
| ▸ | JAK3 | P52333 | 6/20 | 0.53 |
| ▸ | SIRT2 | Q8IXJ6 | 2/20 | 0.53 |
| ▸ | SIRT1 | Q96EB6 | 2/20 | 0.53 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.52 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.47 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.46 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.46 |
| ▸ | MGLL | Q99685 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22470796 | 0.90 | ACSS2 (0.52) | HSD17B10KMT2AJAK2JAK1TYK2 | |
| SCHEMBL5317401 | 0.90 | HSD17B10 (0.73) | HSD17B10KMT2ASIRT2SIRT1FGFR1 | |
| SCHEMBL1623811 | 0.84 | JAK2 (0.56) | HSD17B10KMT2AJAK2JAK1TYK2 | |
| SCHEMBL27599850 | 0.84 | TP53 (0.55) | HSD17B10KMT2AJAK2JAK1TYK2 | |
| SCHEMBL1625910 | 0.84 | KMT2A (0.50) | HSD17B10KMT2AJAK2JAK1TYK2 | |
| SCHEMBL1625941 | 0.83 | KMT2A (0.49) | HSD17B10KMT2AJAK2JAK1TYK2 | |
| SCHEMBL5809308 | 0.81 | FGFR1 (0.57) | HSD17B10KMT2AJAK2JAK1TYK2 | |
| SCHEMBL30832791 | 0.79 | KMT2A (0.50) | HSD17B10KMT2AJAK2JAK1TYK2 | |
| SCHEMBL25112562 | 0.79 | PDE10A (0.63) | SIRT2SIRT1FGFR1PDE10AALDH1A1 | |
| SCHEMBL27582731 | 0.79 | TP53 (0.45) | HSD17B10KMT2AJAK2JAK1TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1499305-A2 | USE OF EP4 RECEPTOR LIGANDS IN THE TREATMENT OF IL-6 INVOLVED DISEASES | Pfizer Japan Inc. (JP) | 2005-01-26 | — | — | EP | disclosed |
| WO-2003086371-A2 | USE OF EP4 RECEPTOR LIGANDS IN THE TREATMENT OF IL-6 INVOLVED DISEASES | PFIZER JAPAN INC. (JP) | 2003-10-23 | — | — | WO | disclosed |