Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 known ✓ | P08172 | 2/20 | 0.41 |
| ▸ | CHRM1 known ✓ | P11229 | 1/20 | 0.40 |
| ▸ | CHRM3 known ✓ | P20309 | 1/20 | 0.40 |
| ▸ | ASAH1 | Q13510 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | ACER2 | Q5QJU3 | 1/20 | 0.51 |
| ▸ | DNM1 | Q05193 | 2/20 | 0.46 |
| ▸ | NAAA | Q02083 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 3/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | ADRA2C | P18825 | 3/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL29992023 | 1.00 | ASAH1 (0.51) | ASAH1ALDH1A1ACER2DNM1NAAA | |
| Bromide SCHEMBL3571270 | 1.00 | ASAH1 (0.51) | ASAH1ALDH1A1ACER2DNM1NAAA | |
| SCHEMBL4656281 | 0.98 | ASAH1 (0.52) | ASAH1ALDH1A1ACER2DNM1NAAA | |
| SCHEMBL16784107 | 0.98 | ASAH1 (0.52) | ASAH1ALDH1A1ACER2DNM1NAAA | |
| Hydrochloric Acid SCHEMBL11172132 | 0.97 | ASAH1 (0.51) | ASAH1ALDH1A1ACER2DNM1NAAA | |
| Bromide SCHEMBL25252124 | 0.80 | ADRA2C (0.48) | ASAH1ALDH1A1ACER2MEN1KMT2A | |
| Bromide SCHEMBL26653709 | 0.80 | ADRA2C (0.48) | ASAH1ALDH1A1ACER2MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL27777948 | 0.80 | SMN1; SMN2 (0.50) | ASAH1ALDH1A1ACER2DNM1NAAA | |
| Bromide SCHEMBL10424888 | 0.79 | DNM1 (0.44) | ASAH1ALDH1A1ACER2DNM1NAAA | |
| SCHEMBL9396434 | 0.79 | DNM1 (0.50) | ASAH1ALDH1A1ACER2DNM1NAAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070123656-A1 | Polyolefin graft copolymer | KANEKA CORPORATION (JP) | 2007-05-31 | — | — | US | disclosed |
| EP-1671985-A1 | POLYOLEFIN GRAFT COPOLYMER | KANEKA CORPORATION (JP) | 2006-06-21 | — | — | EP | disclosed |