Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNC | P24863 | 7/20 | 0.48 |
| ▸ | CDK8 | P49336 | 7/20 | 0.48 |
| ▸ | PDGFRA | P16234 | 5/20 | 0.46 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.46 |
| ▸ | KDR | P35968 | 5/20 | 0.42 |
| ▸ | MET | P08581 | 3/20 | 0.42 |
| ▸ | AURKA | O14965 | 2/20 | 0.42 |
| ▸ | LCK | P06239 | 2/20 | 0.42 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.42 |
| ▸ | TEK | Q02763 | 1/20 | 0.42 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.41 |
| ▸ | DDR2 | Q16832 | 2/20 | 0.41 |
| ▸ | KIT | P10721 | 2/20 | 0.41 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.41 |
| ▸ | PLK4 | O00444 | 1/20 | 0.41 |
| ▸ | GAK | O14976 | 1/20 | 0.41 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.41 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.41 |
| ▸ | STK10 | O94804 | 1/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5598854 | 0.87 | CCNC (0.44) | CCNCCDK8PDGFRAPDGFRBKDR | |
| SCHEMBL2175230 | 0.84 | KDR (0.53) | PDGFRAPDGFRBKDRMETAURKA | |
| SCHEMBL5598959 | 0.80 | PDGFRB (0.52) | CCNCCDK8PDGFRAPDGFRBKDR | |
| SCHEMBL5598545 | 0.75 | PDGFRB (0.49) | CCNCCDK8PDGFRAPDGFRBKDR | |
| SCHEMBL5598589 | 0.73 | PDGFRB (0.48) | CCNCCDK8PDGFRAPDGFRBKDR | |
| SCHEMBL30946604 | 0.73 | PTGS2 (0.57) | — | |
| SCHEMBL490635 | 0.73 | PTGS2 (0.57) | — | |
| SCHEMBL24011308 | 0.73 | CCNC (0.50) | CCNCCDK8PDGFRAPDGFRBEGFR | |
| SCHEMBL5591912 | 0.72 | PDGFRB (0.50) | CCNCCDK8PDGFRAPDGFRBKDR | |
| SCHEMBL2175628 | 0.72 | MET (0.50) | PDGFRAPDGFRBKDRMETAURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007113565-A1 | NAPHTHYRIDINE DERIVATIVES AS ANTI-CANCER AGENTS | ASTRAZENECA AB (SE) | 2007-10-11 | — | — | WO | disclosed |