Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NFKB1 | P19838 | 2/20 | 0.65 |
| ▸ | JUN | P05412 | 1/20 | 0.65 |
| ▸ | FDPS | P14324 | 3/20 | 0.63 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.62 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.62 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.62 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.61 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.61 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.61 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.61 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.61 |
| ▸ | STAT3 | P40763 | 1/20 | 0.61 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.61 |
| ▸ | RELA | Q04206 | 1/20 | 0.61 |
| ▸ | TXNRD1 | Q16881 | 1/20 | 0.60 |
| ▸ | TXNRD3 | Q86VQ6 | 1/20 | 0.60 |
| ▸ | TXNRD2 | Q9NNW7 | 1/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.59 |
| ▸ | HPGD | P15428 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5598661 | 1.00 | NFKB1 (0.65) | NFKB1JUNFDPSHDAC1HDAC2 | |
| SCHEMBL2743993 | 0.94 | NFKB1 (0.56) | NFKB1JUNFDPSHDAC1HDAC2 | |
| SCHEMBL2743988 | 0.94 | NFKB1 (0.56) | NFKB1JUNFDPSHDAC1HDAC2 | |
| SCHEMBL2744110 | 0.93 | BACE1 (0.64) | NFKB1JUNFDPSHDAC1HDAC2 | |
| SCHEMBL2744681 | 0.93 | CYP2D6 (0.74) | NFKB1JUNHDAC1HDAC2HDAC8 | |
| SCHEMBL14571887 | 0.93 | MAPT (0.59) | NFKB1JUNFDPSHDAC1HDAC2 | |
| SCHEMBL2744676 | 0.93 | CYP2D6 (0.74) | NFKB1JUNHDAC1HDAC2HDAC8 | |
| SCHEMBL2744107 | 0.93 | BACE1 (0.64) | NFKB1JUNFDPSHDAC1HDAC2 | |
| SCHEMBL5598627 | 0.90 | FDPS (0.79) | NFKB1JUNFDPSHDAC1HDAC2 | |
| SCHEMBL7290486 | 0.90 | KDM4E (0.75) | FDPSHDAC1HDAC2HDAC8NFE2L2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160039734-A1 | THERAPEUTIC CURCUMIN DERIVATIVES | STC UNM (US) | 2016-02-11 | — | — | US | disclosed |
| US-9187397-B2 | Therapeutic curcumin derivatives | STC.UNM (US) | 2015-11-17 | — | — | US | disclosed |
| US-20150011494-A1 | THERAPEUTIC CURCUMIN DERIVATIVES | STC.UNM | 2015-01-08 | — | — | US | disclosed |
| US-8841326-B2 | Therapeutic curcumin derivatives | STC.UNM (US) | 2014-09-23 | — | — | US | disclosed |
| US-20070060644-A1 | Therapeutic curcumin derivatives | STC.UNM | 2007-03-15 | — | — | US | disclosed |
| US-20060276536-A1 | Cancer treatment using curcumin derivatives | STC.UNM | 2006-12-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160039734-A1 | THERAPEUTIC CURCUMIN DERIVATIVES | FABP2, GLS2, FABP1 | NFKB1 418/4885JUN 2204/4885FDPS 2838/4885 |
| US-20070060644-A1 | Therapeutic curcumin derivatives | FABP2, GLS2, FABP1 | NFKB1 418/4885JUN 2204/4885FDPS 2838/4885 |
| US-20150011494-A1 | THERAPEUTIC CURCUMIN DERIVATIVES | FABP2, GLS2, FABP1 | NFKB1 418/4885JUN 2204/4885FDPS 2838/4885 |
| US-20060276536-A1 | Cancer treatment using curcumin derivatives | BRCA1, VHL, TP53 | NFKB1 73/4885JUN 786/4885FDPS 2157/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.