Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Arginine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OTC | P00480 | 1/20 | 0.46 |
| ▸ | NOS2 | P35228 | 8/20 | 0.44 |
| ▸ | NOS1 | P29475 | 7/20 | 0.44 |
| ▸ | NOS3 | P29474 | 5/20 | 0.44 |
| ▸ | DDAH1 | O94760 | 4/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | GSR | P00390 | 1/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | APEX1 | P27695 | 1/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| L-Citrulline SCHEMBL8174339 | 0.88 | OTC (0.48) | OTCNOS2NOS1NOS3DDAH1 | |
| L-Citrulline SCHEMBL8174334 | 0.88 | OTC (0.48) | OTCNOS2NOS1NOS3DDAH1 | |
| Arginine SCHEMBL27797253 | 0.88 | OTC (0.53) | OTCNOS2NOS1NOS3DDAH1 | |
| Arginine SCHEMBL28280254 | 0.88 | OTC (0.53) | OTCNOS2NOS1NOS3DDAH1 | |
| Arginine SCHEMBL6374054 | 0.87 | OTC (0.56) | OTCNOS2NOS1NOS3DDAH1 | |
| Arginine SCHEMBL1790 | 0.87 | OTC (0.56) | OTCNOS2NOS1NOS3DDAH1 | |
| Arginine SCHEMBL288132 | 0.87 | OTC (0.56) | OTCNOS2NOS1NOS3DDAH1 | |
| Arginine SCHEMBL7928810 | 0.87 | OTC (0.56) | OTCNOS2NOS1NOS3DDAH1 | |
| Arginine SCHEMBL2411547 | 0.87 | OTC (0.56) | OTCNOS2NOS1NOS3DDAH1 | |
| Arginine SCHEMBL31663499 | 0.87 | OTC (0.56) | OTCNOS2NOS1NOS3DDAH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7186687-B2 | Compositions and methods for treatment of Psoriasis | PROCYTE CORPORATION (US) | 2007-03-06 | — | — | US | disclosed |