Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | PARP1 | P09874 | 10/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.42 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | CD38 | P28907 | 1/20 | 0.38 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16884624 | 0.92 | PARP1 (0.41) | PARP1PARP2 | |
| SCHEMBL4392864 | 0.87 | PTGDR2 (0.44) | KDM4EKMT2APTGDR2HTT | |
| SCHEMBL5599730 | 0.86 | PARP1 (0.40) | KDM4EPARP1PARP2 | |
| SCHEMBL27003074 | 0.80 | KDM4E (0.48) | KDM4EMEN1MAPTKMT2APARP1 | |
| SCHEMBL4141787 | 0.80 | KDM4E (0.48) | KDM4EMEN1MAPTKMT2APARP1 | |
| SCHEMBL30100529 | 0.80 | KDM4E (0.58) | KDM4EMEN1MAPTKMT2APARP1 | |
| SCHEMBL307050 | 0.79 | KDM4E (0.53) | KDM4EMEN1MAPTKMT2APARP1 | |
| SCHEMBL1514834 | 0.78 | NOTUM (0.43) | KDM4EMAPTPTGDR2 | |
| SCHEMBL31270723 | 0.78 | KDM4E (0.53) | KDM4EMEN1MAPTKMT2APARP1 | |
| SCHEMBL18222674 | 0.78 | KDM4E (0.53) | KDM4EMEN1MAPTKMT2APARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101962384-A | Chromene compounds, a process for their preparation and pharmaceutical compositions containing them | SERVIER LAB | 2011-02-02 | — | — | CN | claimed |
| CN-101962384-B | Chromene compounds, a process for their preparation and pharmaceutical compositions containing them | SERVIER LAB | 2013-04-10 | — | — | CN | disclosed |
| CN-101962384-A | Chromene compounds, a process for their preparation and pharmaceutical compositions containing them | SERVIER LAB | 2011-02-02 | — | — | CN | disclosed |
| EP-1740584-A1 | FUSED QUINOLINE DERIVATIVE AND USE THEREOF | Takeda Pharmaceutical Company Limited (JP) | 2007-01-10 | — | — | EP | disclosed |
| WO-2005105802-A1 | FUSED QUINOLINE DERIVATIVE AND USE THEREOF | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2005-11-10 | — | — | WO | disclosed |