Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 4/20 | 0.44 |
| ▸ | KMO | O15229 | 1/20 | 0.42 |
| ▸ | ACMSD | Q8TDX5 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | ABCC1 | P33527 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.38 |
| ▸ | CLCN2 | P51788 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1514834 | 0.92 | NOTUM (0.43) | PTGDR2ALDH1A1CYP1A2HPGDHSD17B10 | |
| SCHEMBL5599182 | 0.87 | KDM4E (0.44) | PTGDR2KDM4EHTTKMT2A | |
| SCHEMBL5001042 | 0.87 | NOTUM (0.40) | PTGDR2ALDH1A1CYP1A2HPGDHSD17B10 | |
| SCHEMBL5001048 | 0.87 | NOTUM (0.40) | PTGDR2ALDH1A1CYP1A2HPGDHSD17B10 | |
| SCHEMBL5520149 | 0.84 | ACMSD (0.40) | PTGDR2KMOACMSD | |
| SCHEMBL8447500 | 0.82 | CYP2C9 (0.43) | ALDH1A1CYP1A2HPGDHSD17B10KMT2A | |
| SCHEMBL3096090 | 0.81 | PTGDR2 (0.40) | PTGDR2KMOACMSDALDH1A1CYP1A2 | |
| SCHEMBL30281099 | 0.79 | DRD2 (0.45) | ALDH1A1HPGDHSD17B10KDM4E | |
| SCHEMBL11205492 | 0.79 | PTGDR2 (0.40) | PTGDR2KDM4EKMT2ATDP1 | |
| SCHEMBL9403931 | 0.79 | ACMSD (0.50) | PTGDR2KMOACMSDALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2091949-A1 | INDOLE DERIVATIVES AS S1P1 RECEPTOR AGONISTS | Glaxo Group Limited (GB) | 2009-08-26 | — | — | EP | disclosed |
| WO-2008074821-A1 | INDOLE DERIVATIVES AS S1P1 RECEPTOR AGONISTS | GLAXO GROUP LIMITED (GB) | 2008-06-26 | — | — | WO | disclosed |