Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | TP53 | P04637 | 3/20 | 0.40 |
| ▸ | TSHR | P16473 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | HPGD | P15428 | 3/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | PKM | P14618 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | PPARG | P37231 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.35 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5599194 | 0.81 | ALDH1A1 (0.45) | TDP1ALDH1A1TP53TSHRHIF1A | |
| SCHEMBL1673411 | 0.75 | TDP1 (0.51) | TDP1ALDH1A1TP53TSHRMAPT | |
| SCHEMBL9176540 | 0.75 | ALDH1A1 (0.44) | TDP1ALDH1A1TP53TSHRMAPT | |
| SCHEMBL29411927 | 0.71 | TDP1 (0.68) | TDP1ALDH1A1TP53TSHRMAPT | |
| SCHEMBL21094081 | 0.69 | TDP1 (0.79) | TDP1ALDH1A1TP53TSHRMAPT | |
| SCHEMBL20677146 | 0.69 | TDP1 (0.79) | TDP1ALDH1A1TP53TSHRMAPT | |
| SCHEMBL50264 | 0.69 | TDP1 (0.79) | TDP1ALDH1A1TP53TSHRMAPT | |
| SCHEMBL15934082 | 0.68 | TDP1 (0.53) | TDP1ALDH1A1TP53TSHRMAPT | |
| SCHEMBL17902752 | 0.68 | TDP1 (0.66) | TDP1ALDH1A1TP53TSHRMAPT | |
| SCHEMBL16527790 | 0.68 | TDP1 (0.66) | TDP1ALDH1A1TP53TSHRMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070135607-A1 | TDI prepolymers with improved processing characteristics | ROSTHAUSER JAMES W | 2007-06-14 | — | — | US | disclosed |
| EP-0915110-B1 | Reactivity improvement of urethane prepolymers of allophanate-modified diphenylmethane diisocyanates | BAYER AG (US) | 2004-12-29 | — | — | EP | disclosed |
| EP-1122271-B1 | Process for the preparation of polyisocyanate compositions based on MDI with improved freeze stability | BAYER AG (US) | 2004-03-31 | — | — | EP | disclosed |
| US-6482913-B1 | Liquid MDI adducts wtih improved freeze stability | BAYER AKTIENGESELLSCHAFT (DE) | 2002-11-19 | — | — | US | disclosed |
| EP-1122271-A1 | Liquid MDI adducts with improved freeze stability | Bayer Corporation (US) | 2001-08-08 | — | — | EP | disclosed |
| US-6127463-A | ADDING A COMPOUND THAT CONTAINS AN EPOXIDE GROUP TO THE PROCESS AT ANY POINT PRIOR TO QUENCH COOLING THE FORMED POLYISOCYANATES | BAYER CORPORATION (US) | 2000-10-03 | — | — | US | disclosed |
| EP-0915110-A1 | Reactivity improvement of urethane prepolymers of allophanate-modified diphenylmethane diisocyanates | Bayer Corporation (US) | 1999-05-12 | — | — | EP | disclosed |
| EP-0844276-A1 | Reactivity stabilization of polymethylene poly(phenylisocyanates) | Bayer Corporation (US) | 1998-05-27 | — | — | EP | disclosed |
| EP-0631532-B1 | THERMOSETTING BINDER FOR AN ABRASIVE ARTICLE | MINNESOTA MINING & MFG (US) | 1996-05-22 | — | — | EP | disclosed |
| US-5451446-A | Polyepoxides | MINNESOTA MINING AND MANUFACTURING COMPANY (US) | 1995-09-19 | — | — | US | disclosed |