Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 9/20 | 0.44 |
| ▸ | HTR7 | P34969 | 9/20 | 0.44 |
| ▸ | DRD2 | P14416 | 8/20 | 0.44 |
| ▸ | HTR6 | P50406 | 2/20 | 0.43 |
| ▸ | PER2 | O15055 | 2/20 | 0.43 |
| ▸ | CRY2 | Q49AN0 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | DRD1 | P21728 | 1/20 | 0.40 |
| ▸ | DRD4 | P21917 | 1/20 | 0.40 |
| ▸ | DRD3 | P35462 | 1/20 | 0.40 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.40 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5598889 | 1.00 | HTR1A (0.44) | HTR1AHTR7DRD2HTR6PER2 | |
| SCHEMBL5598874 | 1.00 | HTR1A (0.44) | HTR1AHTR7DRD2HTR6PER2 | |
| Hydrochloric Acid SCHEMBL5599083 | 0.99 | HTR1A (0.45) | HTR1AHTR7DRD2HTR6PER2 | |
| SCHEMBL4522919 | 0.90 | HTR1A (0.42) | HTR1AHTR7DRD2HTR6DRD1 | |
| Hydrochloric Acid SCHEMBL4525100 | 0.89 | HTR1A (0.43) | HTR1AHTR7DRD2HTR6DRD1 | |
| SCHEMBL4528441 | 0.82 | ADRA1D (0.53) | HTR1AHTR7DRD2HTR6ADRA1D | |
| Hydrochloric Acid SCHEMBL4534062 | 0.81 | ADRA1D (0.52) | HTR1AHTR7DRD2HTR6ADRA1D | |
| SCHEMBL4521352 | 0.80 | HTR1A (0.47) | HTR1AHTR7DRD2HTR6DRD1 | |
| SCHEMBL5598872 | 0.80 | PDE4B (0.34) | ALDH1A1DRD1DRD4DRD3PRMT5 | |
| Hydrochloric Acid SCHEMBL4517586 | 0.80 | HTR1A (0.47) | HTR1AHTR7DRD2HTR6LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007029078-A2 | SUCCINIMIDE AND GLUTARIMIDE DERIVATIVES AS ADRENERGIC RECEPTOR ANTAGONISTS | RANBAXY LABORATORIES LIMITED (IN) | 2007-03-15 | — | — | WO | disclosed |