Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NFKB1 | P19838 | 7/20 | 1.00 |
| ▸ | NFKB2 | Q00653 | 7/20 | 1.00 |
| ▸ | RELA | Q04206 | 7/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 4/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | MGAM | O43451 | 1/20 | 0.35 |
| ▸ | SI | P14410 | 1/20 | 0.35 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14586681 | 0.79 | NFKB1 (1.00) | NFKB1NFKB2RELAGAA | |
| SCHEMBL5600252 | 0.79 | NFKB1 (1.00) | NFKB1NFKB2RELAGAA | |
| SCHEMBL7338158 | 0.78 | NFKB1 (0.64) | NFKB1NFKB2RELAALDH1A1GAA | |
| SCHEMBL26983435 | 0.77 | NFKB1 (0.64) | NFKB1NFKB2RELA | |
| SCHEMBL14586691 | 0.75 | NFKB1 (0.60) | NFKB1NFKB2RELAALDH1A1CYP1A2 | |
| SCHEMBL12649640 | 0.75 | NFKB1 (0.60) | NFKB1NFKB2RELAALDH1A1CYP1A2 | |
| SCHEMBL18415033 | 0.73 | NFKB1 (0.57) | NFKB1NFKB2RELAALDH1A1CYP1A2 | |
| SCHEMBL5601260 | 0.71 | NFKB1 (0.55) | NFKB1NFKB2RELAALDH1A1SMN1; SMN2 | |
| SCHEMBL6827884 | 0.70 | NFKB1 (0.54) | NFKB1NFKB2RELAALDH1A1CYP1A2 | |
| SCHEMBL18414940 | 0.70 | NFKB1 (0.54) | NFKB1NFKB2RELA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1537066-B1 | CYCLOPENTENONE DERIVATIVES AS POTENT ACTIVATORS OF HSF-1 | BIOGEM S C AR L (IT) | 2017-01-25 | — | — | EP | disclosed |
| EP-1537066-B1 | CYCLOPENTENONE DERIVATIVES AS POTENT ACTIVATORS OF HSF-1 | BIOGEM S C AR L (IT) | 2017-01-25 | — | — | EP | disclosed |
| US-7183440-B2 | Pharmaceutically useful compounds | CHARTERHOUSE THERAPEUTICS LTD (GB) | 2007-02-27 | — | — | US | disclosed |
| US-7183440-B2 | Pharmaceutically useful compounds | CHARTERHOUSE THERAPEUTICS LTD (GB) | 2007-02-27 | — | — | US | disclosed |
| US-7183440-B2 | Pharmaceutically useful compounds | CHARTERHOUSE THERAPEUTICS LTD (GB) | 2007-02-27 | — | — | US | disclosed |
| US-20060040869-A1 | Pharmaceutically useful compounds | BIOGEM S.C.A.R.L. (IT) | 2006-02-23 | — | — | US | disclosed |
| EP-1537066-A2 | IMPROVEMENTS IN PHARMACEUTICALLY USEFUL COMPOUNDS | Charterhouse Therapeutics Ltd. (GB) | 2005-06-08 | — | — | EP | disclosed |
| WO-2004013077-A2 | CYCLOPENTANONE AND CYCLOPENTANONE DERIVATIVES AS POTENT ACTIVATORS OF HSF-1 | CHARTERHOUSE THERAPEUTICS LTD (GB) | 2004-02-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060040869-A1 | Pharmaceutically useful compounds | MC2R, CRKL, NPY2R | NFKB1 2975/4885NFKB2 2252/4885RELA 3671/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.