Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.37 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL5601805 | 0.85 | KDM4E (0.31) | ALDH1A1HSD17B10HPGD | |
| Hydrochloric Acid SCHEMBL5603295 | 0.83 | MAPT (0.31) | ALDH1A1NPSR1MAPTHTT | |
| Hydrochloric Acid SCHEMBL5602550 | 0.82 | ALDH1A1 (0.41) | ALDH1A1NPSR1NOTUMMAPTHTT | |
| Hydrochloric Acid SCHEMBL5602879 | 0.82 | — | — | |
| Hydrochloric Acid SCHEMBL5602274 | 0.80 | MEN1 (0.40) | ALDH1A1NPSR1LMNAKMT2AHSD17B10 | |
| Hydrochloric Acid SCHEMBL5600524 | 0.80 | ESR2 (0.31) | — | |
| Hydrochloric Acid SCHEMBL5600939 | 0.78 | — | — | |
| Hydrochloric Acid SCHEMBL5601937 | 0.77 | NOTUM (0.39) | ALDH1A1NOTUMLMNAMAPTHTT | |
| Hydrochloric Acid SCHEMBL5601498 | 0.76 | — | — | |
| Hydrochloric Acid SCHEMBL5603694 | 0.76 | GRM5 (0.31) | MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7276567-B2 | Heterocyclic substituted metallocene compounds for olefin polymerization | EXXONMOBIL CHEMICAL PATENTS INC. (US) | 2007-10-02 | — | — | US | disclosed |
| US-20050261449-A1 | Heterocyclic substituted metallocene compounds for olefin polymerization | EXXONMOBIL CHEMICAL PATENT INC. | 2005-11-24 | — | — | US | disclosed |