Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.60 |
| ▸ | NPC1 | O15118 | 5/20 | 0.60 |
| ▸ | RAB9A | P51151 | 5/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.60 |
| ▸ | THRB | P10828 | 1/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.59 |
| ▸ | MEN1 | O00255 | 3/20 | 0.59 |
| ▸ | HPGD | P15428 | 1/20 | 0.59 |
| ▸ | HTT | P42858 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 2/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.56 |
| ▸ | PLAAT3 | P53816 | 2/20 | 0.55 |
| ▸ | PLAAT5 | Q96KN8 | 2/20 | 0.55 |
| ▸ | PLAAT2 | Q9NWW9 | 2/20 | 0.55 |
| ▸ | PLAAT4 | Q9UL19 | 2/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.55 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.54 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.53 |
| ▸ | CNR1 | P21554 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2304984 | 0.86 | APEX1 (0.60) | NPC1ALDH1A1KMT2AMEN1HPGD | |
| SCHEMBL2309244 | 0.85 | MAPT (0.72) | SMN1; SMN2NPC1RAB9AALDH1A1KMT2A | |
| SCHEMBL19579563 | 0.84 | SMN1; SMN2 (0.67) | SMN1; SMN2NPC1RAB9AALDH1A1THRB | |
| SCHEMBL8218590 | 0.80 | NPC1 (0.71) | SMN1; SMN2NPC1RAB9AALDH1A1KMT2A | |
| SCHEMBL1196389 | 0.78 | L3MBTL1 (0.70) | SMN1; SMN2NPC1RAB9AALDH1A1THRB | |
| SCHEMBL28631718 | 0.76 | SMN1; SMN2 (0.58) | SMN1; SMN2NPC1RAB9AALDH1A1THRB | |
| SCHEMBL31683858 | 0.76 | SMN1; SMN2 (0.58) | SMN1; SMN2NPC1RAB9AALDH1A1THRB | |
| SCHEMBL4525519 | 0.76 | ALDH1A1 (0.72) | SMN1; SMN2NPC1RAB9AALDH1A1THRB | |
| SCHEMBL4650799 | 0.76 | HIF1A (0.59) | NPC1RAB9AL3MBTL1HIF1ACNR1 | |
| SCHEMBL8162947 | 0.76 | HIF1A (0.72) | SMN1; SMN2NPC1RAB9AALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007070816-A2 | THIOPHENE DERIVATIVES AS FACTOR XIA INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2007-06-21 | — | — | WO | disclosed |