Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 5/20 | 0.41 |
| ▸ | F2 | P00734 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | KCNJ1 | P48048 | 3/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6064749 | 0.81 | NOTUM (0.42) | NOTUMF2ALDH1A1NPSR1KCNJ1 | |
| Hydrochloric Acid SCHEMBL5600537 | 0.81 | NOTUM (0.42) | NOTUMF2ALDH1A1NPSR1KCNJ1 | |
| Hydrochloric Acid SCHEMBL5602869 | 0.79 | NOTUM (0.41) | NOTUMF2ALDH1A1NPSR1KCNJ1 | |
| Hydrochloric Acid SCHEMBL5603126 | 0.79 | NOTUM (0.32) | NOTUM | |
| Hydrochloric Acid SCHEMBL5601384 | 0.78 | NOTUM (0.31) | NOTUM | |
| Hydrochloric Acid SCHEMBL5602504 | 0.78 | — | — | |
| Hydrochloric Acid SCHEMBL5602500 | 0.77 | CYP2A6 (0.37) | ALDH1A1KDM4ELMNA | |
| Hydrochloric Acid SCHEMBL5602671 | 0.76 | NOTUM (0.38) | NOTUMALDH1A1NPSR1KMT2AMAPT | |
| SCHEMBL5603675 | 0.75 | NOTUM (0.40) | NOTUMF2ALDH1A1NPSR1KCNJ1 | |
| SCHEMBL5602875 | 0.75 | NOTUM (0.40) | NOTUMF2ALDH1A1NPSR1KCNJ1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7276567-B2 | Heterocyclic substituted metallocene compounds for olefin polymerization | EXXONMOBIL CHEMICAL PATENTS INC. (US) | 2007-10-02 | — | — | US | disclosed |
| US-20050261449-A1 | Heterocyclic substituted metallocene compounds for olefin polymerization | EXXONMOBIL CHEMICAL PATENT INC. | 2005-11-24 | — | — | US | disclosed |