Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B2 | P19099 | 6/20 | 0.46 |
| ▸ | CYP11B1 | P15538 | 5/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.42 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | IDO1 | P14902 | 1/20 | 0.38 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL5602504 | 0.83 | — | — | |
| Hydrochloric Acid SCHEMBL5601398 | 0.82 | — | — | |
| Hydrochloric Acid SCHEMBL5603425 | 0.79 | CYP11B2 (0.43) | CYP11B2CYP11B1CYP3A4CYP19A1MEN1 | |
| Hydrochloric Acid SCHEMBL5603894 | 0.79 | CYP11B2 (0.43) | CYP11B2CYP11B1CYP3A4CYP19A1MEN1 | |
| Hydrochloric Acid SCHEMBL5603247 | 0.79 | CYP11B2 (0.37) | CYP11B2CYP11B1CYP3A4CYP19A1MEN1 | |
| Hydrochloric Acid SCHEMBL5601543 | 0.77 | CYP11B2 (0.36) | CYP11B2CYP11B1CYP3A4CYP19A1 | |
| SCHEMBL5603826 | 0.77 | CYP11B2 (0.41) | CYP11B2CYP11B1CYP3A4CYP19A1MEN1 | |
| SCHEMBL5603897 | 0.77 | CYP11B2 (0.41) | CYP11B2CYP11B1CYP3A4CYP19A1MEN1 | |
| SCHEMBL5603432 | 0.77 | CYP11B2 (0.41) | CYP11B2CYP11B1CYP3A4CYP19A1MEN1 | |
| Hydrochloric Acid SCHEMBL5602557 | 0.76 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7276567-B2 | Heterocyclic substituted metallocene compounds for olefin polymerization | EXXONMOBIL CHEMICAL PATENTS INC. (US) | 2007-10-02 | — | — | US | disclosed |
| US-20050261449-A1 | Heterocyclic substituted metallocene compounds for olefin polymerization | EXXONMOBIL CHEMICAL PATENT INC. | 2005-11-24 | — | — | US | disclosed |