Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 2/20 | 0.43 |
| ▸ | CA2 | P00918 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | TRPA1 | O75762 | 4/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | PARP1 | P09874 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | MAOA | P21397 | 1/20 | 0.32 |
| ▸ | MAOB | P27338 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14612944 | 0.75 | EGFR (0.30) | — | |
| SCHEMBL31586332 | 0.72 | TRPA1 (0.50) | CA1CA2MAPTTRPA1GAA | |
| SCHEMBL283346 | 0.72 | TRPA1 (0.50) | CA1CA2MAPTTRPA1GAA | |
| SCHEMBL23581856 | 0.67 | PARP1 (0.39) | CA1CA2ALDH1A1MAPTTRPA1 | |
| SCHEMBL10546234 | 0.67 | CA1 (0.42) | CA1CA2MAPTTRPA1GAA | |
| SCHEMBL27986120 | 0.66 | PARP1 (0.41) | CA1CA2ALDH1A1MAPTTRPA1 | |
| SCHEMBL11781237 | 0.66 | TRPA1 (0.41) | MAPTTRPA1GAAMAOAMAOB | |
| SCHEMBL14612943 | 0.66 | GSK3A (0.43) | — | |
| SCHEMBL11784140 | 0.64 | TRPA1 (0.45) | CA1CA2TRPA1PARP1 | |
| Indene SCHEMBL28699208 | 0.64 | CA1 (0.61) | CA1CA2ALDH1A1MAPTTRPA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1776119-A1 | TETRAHYDRO-NAPHTHALENE DERIVATIVES AS GLUCOCORTICOID RECEPTOR MODULATORS | GLAXO GROUP LIMITED (GB) | 2007-04-25 | — | — | EP | disclosed |
| WO-2006015870-A1 | TETRAHYDRO-NAPHTHALENE DERIVATIVES AS GLUCOCORTICOID RECEPTOR MODULATORS | GLAXO GROUP LIMITED (GB) | 2006-02-16 | — | — | WO | disclosed |