Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.37 |
| ▸ | HTR2C | P28335 | 2/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | AQP1 | P29972 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.34 |
| ▸ | HTR2B | P41595 | 1/20 | 0.34 |
| ▸ | HTR6 | P50406 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 4/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.33 |
| ▸ | CDK9 | P50750 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | PRNP | P04156 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4713089 | 0.82 | HTR2C (0.40) | HTR2CHTR2APOLBMAPTNPSR1 | |
| SCHEMBL4713088 | 0.81 | HTR2C (0.40) | HTR2CHTR2AAQP1POLBMAPT | |
| SCHEMBL4231133 | 0.80 | AQP1 (0.56) | LMNAHTR2CHTR2AAQP1POLB | |
| SCHEMBL4230043 | 0.80 | AQP1 (0.53) | HTR2CHTR2AAQP1POLBMAPT | |
| SCHEMBL5604768 | 0.79 | HTR2C (0.37) | HTR2CHTR2APOLBMAPTNPSR1 | |
| SCHEMBL4231138 | 0.78 | AQP1 (0.43) | HTR2CHTR2AAQP1POLBMAPT | |
| SCHEMBL4597091 | 0.73 | HTR2A (0.46) | HTR2CHTR2ANPSR1HTTALDH1A1 | |
| SCHEMBL4226280 | 0.72 | MCOLN3 (0.36) | LMNAAQP1MAPTNPSR1HTT | |
| SCHEMBL4220505 | 0.72 | AQP1 (0.59) | HTR2CHTR2AAQP1NPSR1HTT | |
| SCHEMBL4597088 | 0.72 | HTR2A (0.47) | HTR2CHTR2AAQP1POLBNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2007509174-A | — | — | 2007-04-12 | — | — | JP | claimed |
| EP-1675840-A1 | DIHYDROBENZOFURANYL ALKANAMINE DERIVATIVES AS 5HT2C AGONISTS | Wyeth a Corporation of the State of Delaware (US) | 2006-07-05 | — | — | EP | claimed |
| WO-2005044812-A1 | DIHYDROBENZOFURANYL ALKANAMINE DERIVATIVES AS 5HT2C AGONISTS | WYETH A CORPORATION OF THE STATE OF DELAWARE (US) | 2005-05-19 | — | — | WO | claimed |