Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 2/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | HTR6 | P50406 | 2/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
| ▸ | HTR2B | P41595 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.35 |
| ▸ | HPGD | P15428 | 4/20 | 0.35 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | PRNP | P04156 | 1/20 | 0.34 |
| ▸ | PPARG | P37231 | 1/20 | 0.34 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.34 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.34 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5605916 | 0.89 | MAPT (0.35) | HTR2CHTR6SLC6A4HTR2BALDH1A1 | |
| SCHEMBL4713089 | 0.84 | HTR2C (0.40) | HTR2CHTR2ARECQLHTR6SLC6A4 | |
| SCHEMBL4713088 | 0.83 | HTR2C (0.40) | HTR2CHTR2AHTR6SLC6A4HTR2B | |
| SCHEMBL5605796 | 0.81 | MAPK14 (0.40) | ALDH1A1HPGDKDM4ENPSR1TDP1 | |
| SCHEMBL4230043 | 0.81 | AQP1 (0.53) | HTR2CHTR2AHTR6SLC6A4HTR2B | |
| SCHEMBL4231133 | 0.79 | AQP1 (0.56) | HTR2CHTR2AHTR6SLC6A4HTR2B | |
| SCHEMBL4231138 | 0.79 | AQP1 (0.43) | HTR2CHTR2AHTR6SLC6A4HTR2B | |
| SCHEMBL5604772 | 0.79 | LMNA (0.37) | HTR2CHTR2AHTR6SLC6A4HTR2B | |
| SCHEMBL5606037 | 0.78 | DPP4 (0.37) | ALDH1A1KDM4EHSD17B10MAPTTSHR | |
| SCHEMBL4790775 | 0.77 | AQP1 (0.35) | HTR2CRECQLHTR6SLC6A4HTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2007509174-A | — | — | 2007-04-12 | — | — | JP | claimed |
| EP-1675840-A1 | DIHYDROBENZOFURANYL ALKANAMINE DERIVATIVES AS 5HT2C AGONISTS | Wyeth a Corporation of the State of Delaware (US) | 2006-07-05 | — | — | EP | claimed |
| WO-2005044812-A1 | DIHYDROBENZOFURANYL ALKANAMINE DERIVATIVES AS 5HT2C AGONISTS | WYETH A CORPORATION OF THE STATE OF DELAWARE (US) | 2005-05-19 | — | — | WO | claimed |