Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 4/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.40 |
| ▸ | F10 | P00742 | 1/20 | 0.40 |
| ▸ | PDE4A | P27815 | 1/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.39 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.39 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.39 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3668110 | 0.95 | HPGD (0.42) | HPGDL3MBTL1ALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL8496732 | 0.89 | CHRNA7 (0.42) | HPGDCHRNA7PDE4APDE4BPDE4C | |
| SCHEMBL28581938 | 0.77 | NR1I2 (0.44) | HPGDALDH1A1CHRNA7PDE4APDE4B | |
| SCHEMBL4327657 | 0.74 | CHRNA7 (0.38) | HPGDALDH1A1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL6796982 | 0.74 | TSHR (0.51) | HPGDL3MBTL1ALDH1A1MEN1KMT2A | |
| SCHEMBL30300654 | 0.74 | CHRNA7 (0.41) | HPGDALDH1A1CYP1A2CYP2C19CHRNA7 | |
| Hydrochloric Acid SCHEMBL1583186 | 0.73 | SLC6A2 (0.38) | HPGDALDH1A1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL27464474 | 0.72 | NR1I2 (0.39) | HPGDL3MBTL1ALDH1A1CHRNA7NR1I2 | |
| SCHEMBL21047585 | 0.71 | NR1I2 (0.37) | HPGDALDH1A1CHRNA7PDE4APDE4B | |
| SCHEMBL14456238 | 0.71 | PDE4A (0.38) | HPGDL3MBTL1ALDH1A1CHRNA7F10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 66 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116478179-B | Thienopyrrolidone derivative as well as preparation method and application thereof | 平湖市浙江工业大学新材料研究院 | 2024-12-06 | — | — | CN | claimed |
| CN-116478179-A | Thienopyrrolidone derivative as well as preparation method and application thereof | 平湖市浙江工业大学新材料研究院 | 2023-07-25 | — | — | CN | claimed |
| CN-116478179-B | Thienopyrrolidone derivative as well as preparation method and application thereof | 平湖市浙江工业大学新材料研究院 | 2024-12-06 | — | — | CN | disclosed |
| CN-116478179-B | Thienopyrrolidone derivative as well as preparation method and application thereof | 平湖市浙江工业大学新材料研究院 | 2024-12-06 | — | — | CN | disclosed |
| CN-116478179-B | Thienopyrrolidone derivative as well as preparation method and application thereof | 平湖市浙江工业大学新材料研究院 | 2024-12-06 | — | — | CN | disclosed |
| CN-117510800-A | Preparation method of thienopyrrole diketone polymer | 大连理工大学 | 2024-02-06 | — | — | CN | disclosed |
| CN-116751190-A | Sulfonyl derivative organic luminescent material and preparation method and application thereof | 华南理工大学 | 2023-09-15 | — | — | CN | disclosed |
| CN-116606284-A | Benzophenone derivative organic luminescent material and preparation method and application thereof | 华南理工大学 | 2023-08-18 | — | — | CN | disclosed |
| CN-115286774-B | Double-cable polymer containing thienopyrrolidone side chain groups, and preparation method and application thereof | 北京化工大学 | 2023-08-11 | — | — | CN | disclosed |
| CN-115286774-B | Double-cable polymer containing thienopyrrolidone side chain groups, and preparation method and application thereof | 北京化工大学 | 2023-08-11 | — | — | CN | disclosed |
| CN-115286774-B | Double-cable polymer containing thienopyrrolidone side chain groups, and preparation method and application thereof | 北京化工大学 | 2023-08-11 | — | — | CN | disclosed |
| CN-1440412-A | Thienopyrrolidinones | HOFFMANN LA ROCHE (CH) | 2003-09-03 | — | — | CN | disclosed |
| EP-1301517-A1 | THIENOPYRROLIDINONES | F. HOFFMANN-LA ROCHE AG (CH) | 2003-04-16 | — | — | EP | disclosed |
| US-20030065187-A1 | Copper-catalyzed formation of carbon-heteroatom and carbon-carbon bonds | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2003-04-03 | — | — | US | disclosed |
| US-6528653-B2 | E.g., 4,6-dihydro 4-(heterocyclic ring-methylene)thieno(2,3-b) pyrrolidin-5-one derivatives; tumor necrosis factor ) inhibitors; anticarcinogenic, -proliferative and -arthritic agents; Alzheimer's disease; cardiovascular disorders | HOFFMANN-LA ROCHE, INC. | 2003-03-04 | — | — | US | disclosed |
| US-6528653-B2 | E.g., 4,6-dihydro 4-(heterocyclic ring-methylene)thieno(2,3-b) pyrrolidin-5-one derivatives; tumor necrosis factor ) inhibitors; anticarcinogenic, -proliferative and -arthritic agents; Alzheimer's disease; cardiovascular disorders | HOFFMANN-LA ROCHE, INC. | 2003-03-04 | — | — | US | disclosed |
| WO-2002085838-A1 | COPPER-CATALYZED FORMATION OF CARBON-HETEROATOM AND CARBON-CARBON BONDS | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2002-10-31 | — | — | WO | disclosed |
| US-20020028841-A1 | Thienopyrrolidinones | F. HOFFMANN-LA ROCHE AG (CH) | 2002-03-07 | — | — | US | disclosed |
| US-20020028841-A1 | Thienopyrrolidinones | F. HOFFMANN-LA ROCHE AG (CH) | 2002-03-07 | — | — | US | disclosed |
| WO-2002002567-A1 | THIENOPYRROLIDINONES | F. HOFFMANN-LA ROCHE AG (CH) | 2002-01-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030065187-A1 | Copper-catalyzed formation of carbon-heteroatom and carbon-carbon bonds | ADH5, CBR3, ALDH3A1 | HPGD 613/4885L3MBTL1 1527/4885ALDH1A1 26/4885 |
| US-20020028841-A1 | Thienopyrrolidinones | TNF, TYMP, TNFRSF1A | HPGD 85/4885L3MBTL1 1813/4885ALDH1A1 2036/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.