SCHEMBL5605564

SCHEMBL5605564

CN[C@H]1Cc2cc(F)cc(-c3cc(Cl)ccc3C)c2O1

nearest known ligand 0.56

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
AQP1 P29972 3/20 0.56
L3MBTL1 Q9Y468 1/20 0.37
AGPAT2 O15120 1/20 0.33
IDO1 P14902 1/20 0.32
KCNH2 Q12809 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5605280 0.90 AQP1 (0.58) AQP1L3MBTL1KCNH2
SCHEMBL4596827 0.84 AQP1 (0.53) AQP1L3MBTL1AGPAT2IDO1
SCHEMBL4596825 0.82 AQP1 (0.52) AQP1L3MBTL1AGPAT2IDO1
SCHEMBL4230233 0.81 AQP1 (0.59) AQP1L3MBTL1AGPAT2
SCHEMBL4230928 0.81 AQP1 (0.76) AQP1L3MBTL1AGPAT2
SCHEMBL14113171 0.81 AQP1 (0.76) AQP1L3MBTL1AGPAT2
SCHEMBL4230228 0.81 AQP1 (0.59) AQP1L3MBTL1AGPAT2
SCHEMBL27681652 0.79 AQP1 (0.57) AQP1L3MBTL1
SCHEMBL4768493 0.78 AQP1 (0.65) AQP1L3MBTL1AGPAT2KCNH2
Hydrochloric Acid SCHEMBL4960160 0.77 AQP1 (0.67) AQP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-2007509174-A 2007-04-12 JP claimed
EP-1675840-A1 DIHYDROBENZOFURANYL ALKANAMINE DERIVATIVES AS 5HT2C AGONISTS Wyeth a Corporation of the State of Delaware (US) 2006-07-05 EP claimed
WO-2005044812-A1 DIHYDROBENZOFURANYL ALKANAMINE DERIVATIVES AS 5HT2C AGONISTS WYETH A CORPORATION OF THE STATE OF DELAWARE (US) 2005-05-19 WO claimed