SCHEMBL5605686

SCHEMBL5605686

CC1(C(CC(=O)O)NC(=O)OCc2ccccc2)CCCC1

nearest known ligand 0.51

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
CASP1 P29466 14/20 0.51
CYP3A4 P08684 4/20 0.48
TSHR P16473 4/20 0.48
ALDH1A1 P00352 3/20 0.48
SMN1; SMN2 Q16637 1/20 0.47
CYP2C9 P11712 2/20 0.47
LMNA P02545 1/20 0.47
CYP2C19 P33261 1/20 0.47
MEN1 O00255 1/20 0.47
KMT2A Q03164 1/20 0.47
ATM Q13315 1/20 0.46
CTRB1 P17538 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5605395 0.99 CASP1 (0.50) CASP1CYP3A4TSHRALDH1A1SMN1; SMN2
SCHEMBL5605738 0.90 CYP3A4 (0.48) CASP1CYP3A4TSHRALDH1A1SMN1; SMN2
SCHEMBL8267044 0.83 CYP3A4 (0.52) CASP1CYP3A4TSHRALDH1A1SMN1; SMN2
SCHEMBL4971348 0.79 CYP3A4 (0.50) CASP1CYP3A4TSHRALDH1A1SMN1; SMN2
SCHEMBL7950561 0.78 SYK (0.48) CASP1CYP3A4TSHRALDH1A1SMN1; SMN2
SCHEMBL12937431 0.78 CYP3A4 (0.47) CASP1CYP3A4TSHRALDH1A1SMN1; SMN2
SCHEMBL4972190 0.77 CYP3A4 (0.48) CASP1CYP3A4TSHRALDH1A1SMN1; SMN2
SCHEMBL1551802 0.76 CYP3A4 (0.47) CASP1CYP3A4TSHRALDH1A1SMN1; SMN2
SCHEMBL2398018 0.76 KYNU (0.57) CASP1CYP3A4TSHRALDH1A1SMN1; SMN2
SCHEMBL2396183 0.76 KYNU (0.57) CASP1CYP3A4TSHRALDH1A1SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1761485-A1 AMIDINO COMPOUNDS AS CYSTEINE PROTEASE INHIBITORS Schering AG (DE) 2007-03-14 EP disclosed
EP-1664003-A1 HALOALKYL CONTAINING COMPOUNDS AS CYSTEINE PROTEASE INHIBITORS AXYS PHARMACEUTICALS, INC. (US) 2006-06-07 EP disclosed
EP-1663958-A2 HALOALKYL CONTAINING COMPOUNDS AS CYSTEINE PROTEASE INHIBITORS AXYS PHARMACEUTICALS, INC. (US) 2006-06-07 EP disclosed
WO-2005028454-A1 HALOALKYL CONTAINING COMPOUNDS AS CYSTEINE PROTEASE INHIBITORS AXYS PHARMACEUTICALS, INC. (US) 2005-03-31 WO disclosed
WO-2005028429-A2 HALOALKYL CONTAINING COMPOUNDS AS CYSTEINE PROTEASE INHIBITORS AXYS PHARMACEUTICALS, INC. (US) 2005-03-31 WO disclosed
WO-2004108661-A1 AMIDINO COMPOUNDS AS CYSTEINE PROTEASE INHIBITORS AXYS PHARMACEUTICALS (US) 2004-12-16 WO disclosed