Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSF1R | P07333 | 1/20 | 0.60 |
| ▸ | FLT1 | P17948 | 1/20 | 0.60 |
| ▸ | FLT3 | P36888 | 1/20 | 0.60 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.60 |
| ▸ | MEN1 | O00255 | 2/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.56 |
| ▸ | NQO2 | P16083 | 2/20 | 0.55 |
| ▸ | PARP1 | P09874 | 5/20 | 0.54 |
| ▸ | PARP10 | Q53GL7 | 4/20 | 0.54 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.54 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL895009 | 0.90 | PARP1 (0.63) | MEN1KMT2AALDH1A1PARP1PARP10 | |
| SCHEMBL29761319 | 0.90 | PARP1 (0.63) | MEN1KMT2AALDH1A1PARP1PARP10 | |
| SCHEMBL17460287 | 0.85 | CSF1R (0.62) | CSF1RFLT1FLT3MEN1KMT2A | |
| SCHEMBL27315584 | 0.83 | CSF1R (0.56) | CSF1RFLT1FLT3MEN1KMT2A | |
| SCHEMBL3786463 | 0.81 | NQO2 (0.73) | MEN1KMT2AALDH1A1NQO2MAPT | |
| SCHEMBL13075123 | 0.80 | CSF1R (0.48) | CSF1RFLT1FLT3CHEK2MEN1 | |
| SCHEMBL2431097 | 0.80 | PARP1 (0.64) | PARP1MAPTHSD17B10TSHR | |
| SCHEMBL31422694 | 0.80 | PARP1 (0.64) | PARP1MAPTHSD17B10TSHR | |
| SCHEMBL6798003 | 0.80 | ALDH1A1 (0.80) | CHEK2MEN1KMT2AALDH1A1NQO2 | |
| SCHEMBL8577619 | 0.80 | SMN1; SMN2 (0.70) | MEN1KMT2AALDH1A1NQO2HSD17B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1545537-B1 | ALPHA-7 NICOTINIC RECEPTOR AGONISTS AND STATINS IN COMBINATION | ASTRAZENECA AB (SE) | 2007-04-04 | — | — | EP | claimed |
| CN-1400973-A | Novel biarylcarboxamides | ASTRAZENECA AB (SE) | 2003-03-05 | — | — | CN | claimed |
| CN-100345847-C | Novel biarylcarboxamides | ASTRAZENECA AB (SE) | 2007-10-31 | — | — | CN | disclosed |
| CN-1400973-A | Novel biarylcarboxamides | ASTRAZENECA AB (SE) | 2003-03-05 | — | — | CN | disclosed |