Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 7/20 | 0.39 |
| ▸ | HTR7 | P34969 | 7/20 | 0.39 |
| ▸ | SLC6A9 | P48067 | 4/20 | 0.38 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.36 |
| ▸ | AQP1 | P29972 | 3/20 | 0.32 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.32 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.32 |
| ▸ | HTR2A | P28223 | 2/20 | 0.31 |
| ▸ | HTR2C | P28335 | 2/20 | 0.31 |
| ▸ | HTR2B | P41595 | 2/20 | 0.31 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.31 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.31 |
| ▸ | CNR1 | P21554 | 1/20 | 0.31 |
| ▸ | CNR2 | P34972 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5605603 | 0.84 | HTR1A (0.44) | HTR1AHTR7SLC6A9PTGS1PTGS2 | |
| SCHEMBL5583714 | 0.83 | CNR1 (0.39) | HTR1AHTR7SLC6A9CYP2A6AQP1 | |
| SCHEMBL5605796 | 0.81 | MAPK14 (0.40) | HTR1AHTR7 | |
| SCHEMBL5583710 | 0.81 | CYP2A6 (0.39) | HTR1AHTR7SLC6A9CYP2A6AQP1 | |
| SCHEMBL5605843 | 0.78 | CNR1 (0.34) | HTR1AHTR7SLC6A9CYP2A6AQP1 | |
| SCHEMBL4220714 | 0.78 | AQP1 (0.54) | SLC6A9CYP2A6AQP1HRH3 | |
| SCHEMBL4230563 | 0.77 | AQP1 (0.57) | SLC6A9CYP2A6AQP1HRH3 | |
| SCHEMBL4230569 | 0.76 | AQP1 (0.44) | SLC6A9CYP2A6AQP1HRH3 | |
| SCHEMBL4596667 | 0.73 | AQP1 (0.43) | HTR1AHTR7SLC6A9AQP1 | |
| SCHEMBL15758987 | 0.72 | AKR1C2 (0.37) | SLC6A9HTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2007509174-A | — | — | 2007-04-12 | — | — | JP | claimed |
| EP-1675840-A1 | DIHYDROBENZOFURANYL ALKANAMINE DERIVATIVES AS 5HT2C AGONISTS | Wyeth a Corporation of the State of Delaware (US) | 2006-07-05 | — | — | EP | claimed |
| WO-2005044812-A1 | DIHYDROBENZOFURANYL ALKANAMINE DERIVATIVES AS 5HT2C AGONISTS | WYETH A CORPORATION OF THE STATE OF DELAWARE (US) | 2005-05-19 | — | — | WO | claimed |