Known targets — ChEMBL curated mechanism
MMP1MMP13MMP7MMP8polrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Isopropyl Alcohol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 8/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Isopropyl Alcohol SCHEMBL28011473 | 0.96 | TSHR (0.43) | TSHRALDH1A1LMNATDP1 | |
| Chloroform SCHEMBL35119 | 0.88 | — | — | |
| Chloroform SCHEMBL7542885 | 0.88 | TSHR (0.60) | TSHRALDH1A1LMNATDP1TP53 | |
| Chloroform SCHEMBL8927142 | 0.88 | TSHR (0.60) | TSHRALDH1A1LMNATDP1TP53 | |
| Isopropyl Alcohol SCHEMBL3277962 | 0.88 | TSHR (0.60) | TSHRALDH1A1LMNATDP1TP53 | |
| Chloroform SCHEMBL7542887 | 0.88 | TSHR (0.60) | TSHRALDH1A1LMNATDP1TP53 | |
| Isopropyl Alcohol SCHEMBL5167390 | 0.88 | TSHR (0.60) | TSHRALDH1A1LMNATDP1TP53 | |
| Chloroform SCHEMBL2819782 | 0.88 | TSHR (0.60) | TSHRALDH1A1LMNATDP1TP53 | |
| Chloroform SCHEMBL8192102 | 0.88 | TSHR (0.60) | TSHRALDH1A1LMNATDP1TP53 | |
| Chloroform SCHEMBL8927139 | 0.88 | TSHR (0.60) | TSHRALDH1A1LMNATDP1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115837005-A | Carrier composition and preparation method and application thereof | 康汉医药(广州)有限公司 | 2023-03-24 | — | — | CN | disclosed |
| CN-105504019-B | A kind of conjugated biological molecules of antiendotoxin and its preparation and application | 中国人民解放军第三军医大学第一附属医院 | 2019-06-21 | — | — | CN | disclosed |
| CN-104800837-B | The application of hMOF and its small peptide in terms of alleviation or treatment people's arsenic poisoning medicine is prepared | 吉林大学 | 2017-05-31 | — | — | CN | disclosed |
| CN-104800837-A | Application of hMOF (Human Males Absent on the First) and small peptide of hMOF in preparing drug for alleviating or treating human arsenic poisoning | UNIV JILIN | 2015-07-29 | — | — | CN | disclosed |
| US-8080579-B2 | Compositions and methods for treatment of inflammatory bowel disease | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2011-12-20 | — | — | US | disclosed |
| US-20070123499-A1 | Compositions and methods for treatment and prevention of gastrointestinal disorders | REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2007-05-31 | — | — | US | disclosed |
| US-20050203168-A1 | Angiotensin converting enzyme inhibitor use for treatment and prevention of gastrointestinal disorders | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2005-09-15 | — | — | US | disclosed |