Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.53 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 4/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.36 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.36 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.36 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | NAMPT | P43490 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6460660 | 1.00 | MEN1 (0.53) | MEN1KMT2ACYP2C9CYP2C19ALOX15 | |
| SCHEMBL29484650 | 0.96 | CYP2C19 (0.49) | MEN1KMT2ACYP2C9CYP2C19ALOX15 | |
| SCHEMBL676077 | 0.96 | CYP2C19 (0.49) | MEN1KMT2ACYP2C9CYP2C19ALOX15 | |
| SCHEMBL676076 | 0.96 | CYP2C19 (0.49) | MEN1KMT2ACYP2C9CYP2C19ALOX15 | |
| SCHEMBL9208882 | 0.93 | MEN1 (0.51) | MEN1KMT2ACYP2C9CYP2C19ALOX15 | |
| SCHEMBL9601271 | 0.93 | MEN1 (0.51) | MEN1KMT2ACYP2C9CYP2C19ALOX15 | |
| SCHEMBL9600959 | 0.86 | CYP2C9 (0.38) | MEN1KMT2ACYP2C9CYP2C19ALOX15 | |
| SCHEMBL9211867 | 0.86 | CYP2C9 (0.38) | MEN1KMT2ACYP2C9CYP2C19ALOX15 | |
| SCHEMBL8750786 | 0.81 | MEN1 (0.34) | MEN1KMT2ACYP2C9CYP2C19ALOX15 | |
| SCHEMBL8750746 | 0.81 | HDAC1 (0.35) | MEN1KMT2ACYP2C9CYP2C19ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050181066-A1 | Novel use of guanylate cyclase activators for the treatment of respiratory insufficiency | ALTANA PHARMA AG (DE) | 2005-08-18 | — | — | US | claimed |
| EP-0956866-A1 | DRUGS FOR AMELIORATING OPHTHALMIC CIRCULATORY DISTURBANCE | KIRIN BEER KABUSHIKI KAISHA (JP) | 1999-11-17 | — | — | EP | claimed |
| EP-0388528-B1 | Carboximidamide derivatives | KIRIN BREWERY (JP) | 1995-09-27 | — | — | EP | claimed |
| US-5272164-A | Carboximidamide derivatives | KIRIN BEER KABUSHIKI KAISHA (JP) | 1993-12-21 | — | — | US | claimed |
| EP-0388528-A2 | Carboximidamide derivatives | KIRIN BEER KABUSHIKI KAISHA (JP) | 1990-09-26 | — | — | EP | claimed |
| JP-4128265-A | — | — | None | — | — | JP | disclosed |
| EP-1567179-A4 | IRRIGATION SOLUTION AND METHOD FOR INHIBITION OF TUMOR CELL ADHESION, PAIN AND INFLAMMATION | OMEROS CORP (US) | 2007-06-27 | — | — | EP | disclosed |
| EP-1567179-A1 | IRRIGATION SOLUTION AND METHOD FOR INHIBITION OF TUMOR CELL ADHESION, PAIN AND INFLAMMATION | Omeros Corporation (US) | 2005-08-31 | — | — | EP | disclosed |
| US-20050181066-A1 | Novel use of guanylate cyclase activators for the treatment of respiratory insufficiency | ALTANA PHARMA AG (DE) | 2005-08-18 | — | — | US | disclosed |
| WO-2004043479-A1 | IRRIGATION SOLUTION AND METHOD FOR INHIBITION OF TUMOR CELL ADHESION, PAIN AND INFLAMMATION | OMEROS CORPORATION (US) | 2004-05-27 | — | — | WO | disclosed |
| EP-0956866-A1 | DRUGS FOR AMELIORATING OPHTHALMIC CIRCULATORY DISTURBANCE | KIRIN BEER KABUSHIKI KAISHA (JP) | 1999-11-17 | — | — | EP | disclosed |
| EP-0634400-B1 | PYRIDINECARBOXIMIDAMIDE COMPOUND AND USE THEREOF | KIRIN BREWERY (JP) | 1997-04-02 | — | — | EP | disclosed |
| US-5508293-A | TREATING HYPERTENSION, ANGINA PECTORIS | KIRIN BEER KABUSHIKI KAISHA (JP) | 1996-04-16 | — | — | US | disclosed |
| EP-0388528-B1 | Carboximidamide derivatives | KIRIN BREWERY (JP) | 1995-09-27 | — | — | EP | disclosed |
| EP-0634400-A1 | PYRIDINECARBOXIMIDAMIDE COMPOUND AND USE THEREOF | KIRIN BEER KABUSHIKI KAISHA (JP) | 1995-01-18 | — | — | EP | disclosed |
| US-5272164-A | Carboximidamide derivatives | KIRIN BEER KABUSHIKI KAISHA (JP) | 1993-12-21 | — | — | US | disclosed |
| US-5223508-A | Hypotensive agents, vasodilators | KIRIN BEER KABUSHIKI KAISHA (JP) | 1993-06-29 | — | — | US | disclosed |
| US-5166347-A | Hypotensive agents, cardiovascular disorders, antiischemic agents and anticoagulants | KIRIN BEER KABUSHIKI KAISHA (JP) | 1992-11-24 | — | — | US | disclosed |
| JP-H04128265-A | KRN2391 ACID-ADDUCT SALT AND ITS USE | KIRIN BREWERY CO LTD | 1992-04-28 | — | — | JP | disclosed |
| EP-0388528-A2 | Carboximidamide derivatives | KIRIN BEER KABUSHIKI KAISHA (JP) | 1990-09-26 | — | — | EP | disclosed |