Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | OXTR | P30559 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | P2RX3 | P56373 | 9/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3487585 | 0.79 | SMN1; SMN2 (0.36) | NPC1RAB9ALMNAKDM4ETSHR | |
| SCHEMBL5606506 | 0.79 | NR1H2 (0.39) | NPC1LMNAMAPTP2RX3 | |
| SCHEMBL3487918 | 0.79 | SMN1; SMN2 (0.38) | NPC1RAB9ALMNAKDM4EMAPT | |
| SCHEMBL3487021 | 0.74 | LMNA (0.41) | NPC1RAB9ALMNAUSP2POLB | |
| SCHEMBL4478931 | 0.74 | ASAH1 (0.35) | NPC1RAB9ALMNAKDM4ETSHR | |
| SCHEMBL3486895 | 0.74 | SMN1; SMN2 (0.38) | NPC1RAB9ALMNAMAPTP2RX3 | |
| SCHEMBL3487831 | 0.73 | NR1H2 (0.41) | RAB9ALMNATSHRMAPTMEN1 | |
| SCHEMBL3488288 | 0.73 | CA12 (0.41) | NPC1LMNAMAPTMEN1KMT2A | |
| SCHEMBL3488264 | 0.72 | NR1H2 (0.53) | LMNAMAPTMEN1KMT2A | |
| SCHEMBL4470496 | 0.72 | CYP24A1 (0.33) | MAPTP2RX3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1838686-A1 | DERIVATIVES OF ISOTHIAZOL-3(2H)-ONE 1,1-DIOXIDES AS LIVER X RECEPTOR MODULATORS | AstraZeneca AB (SE) | 2007-10-03 | — | — | EP | disclosed |
| WO-2006073363-A1 | DERIVATIVES OF ISOTHIAZOL-3(2H)-ONE 1,1-DIOXIDES AS LIVER X RECEPTOR MODULATORS | ASTRAZENECA AB (SE) | 2006-07-13 | — | — | WO | disclosed |