Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 10/20 | 0.67 |
| ▸ | APP | P05067 | 2/20 | 0.67 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.64 |
| ▸ | CA12 | O43570 | 1/20 | 0.62 |
| ▸ | CA1 | P00915 | 1/20 | 0.62 |
| ▸ | CA2 | P00918 | 1/20 | 0.62 |
| ▸ | CA7 | P43166 | 1/20 | 0.62 |
| ▸ | CA9 | Q16790 | 1/20 | 0.62 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.62 |
| ▸ | MAOA | P21397 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | CASP3 | P42574 | 1/20 | 0.50 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.50 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.50 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.50 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.50 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18937890 | 0.83 | MAOB (0.71) | MAOBAPPNR4A2CA12CA1 | |
| SCHEMBL11601115 | 0.82 | MAOB (0.69) | MAOBAPPNR4A2CA12CA1 | |
| SCHEMBL3618029 | 0.82 | MAOB (0.69) | MAOBAPPNR4A2CA12CA1 | |
| SCHEMBL1578152 | 0.80 | MAOB (1.00) | MAOBAPPNR4A2CA12CA1 | |
| SCHEMBL21568939 | 0.80 | MAOB (0.67) | MAOBAPPNR4A2CA12CA1 | |
| SCHEMBL9440467 | 0.80 | APP (1.00) | MAOBAPPNR4A2 | |
| SCHEMBL20848358 | 0.80 | MAOB (0.67) | MAOBAPPNR4A2CA12CA1 | |
| SCHEMBL22874653 | 0.80 | MAOB (0.67) | MAOBAPPNR4A2CA12CA1 | |
| SCHEMBL21340442 | 0.80 | MAOB (0.69) | MAOBAPPNR4A2NPC1RAB9A | |
| SCHEMBL9327054 | 0.80 | MAOB (0.67) | MAOBAPPNR4A2MAOANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1761480-A2 | NEW MAO-B INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2007-03-14 | — | — | EP | disclosed |
| WO-2006000324-A2 | NEW MAO-B INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2006-01-05 | — | — | WO | disclosed |