Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 8/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | CNR2 | P34972 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3487111 | 0.73 | DGAT1 (0.47) | DGAT1CYP1A2RAB9ANPC1LMNA | |
| SCHEMBL5666285 | 0.72 | KDM1A (0.47) | CYP1A2RAB9ANPC1SMN1; SMN2GAA | |
| SCHEMBL5607270 | 0.72 | KDM1A (0.47) | CYP1A2LMNASMN1; SMN2MAPTMEN1 | |
| SCHEMBL5613996 | 0.71 | MAPT (0.46) | CYP1A2RAB9ANPC1LMNASMN1; SMN2 | |
| SCHEMBL3487298 | 0.69 | NR1H2 (0.62) | DGAT1CYP1A2RAB9ANPC1LMNA | |
| SCHEMBL4504400 | 0.69 | RAB9A (0.52) | DGAT1CYP1A2RAB9ANPC1LMNA | |
| SCHEMBL16773016 | 0.68 | CNR2 (0.69) | DGAT1CYP1A2LMNASMN1; SMN2GAA | |
| SCHEMBL2790485 | 0.68 | MAPT (0.58) | DGAT1CYP1A2RAB9ANPC1LMNA | |
| SCHEMBL13229247 | 0.67 | DGAT1 (0.63) | DGAT1CYP1A2RAB9ANPC1LMNA | |
| SCHEMBL4822517 | 0.67 | DGAT1 (0.46) | DGAT1CYP1A2RAB9ANPC1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1838686-A1 | DERIVATIVES OF ISOTHIAZOL-3(2H)-ONE 1,1-DIOXIDES AS LIVER X RECEPTOR MODULATORS | AstraZeneca AB (SE) | 2007-10-03 | — | — | EP | disclosed |
| WO-2006073363-A1 | DERIVATIVES OF ISOTHIAZOL-3(2H)-ONE 1,1-DIOXIDES AS LIVER X RECEPTOR MODULATORS | ASTRAZENECA AB (SE) | 2006-07-13 | — | — | WO | disclosed |