Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CG | P48736 | 14/20 | 0.46 |
| ▸ | PIK3CD | O00329 | 13/20 | 0.46 |
| ▸ | PIK3CB | P42338 | 11/20 | 0.46 |
| ▸ | PIK3CA | P42336 | 10/20 | 0.46 |
| ▸ | PIK3R1 | P27986 | 8/20 | 0.46 |
| ▸ | PIK3R2 | O00459 | 1/20 | 0.46 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.46 |
| ▸ | HTR1A | P08908 | 1/20 | 0.46 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.46 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.46 |
| ▸ | PRKDC | P78527 | 1/20 | 0.46 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.46 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.46 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.46 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5607807 | 0.92 | PIK3CG (0.44) | PIK3CGPIK3CDPIK3CBPIK3CAPIK3R1 | |
| SCHEMBL5607167 | 0.91 | PIK3CD (0.45) | PIK3CGPIK3CDPIK3CBPIK3CAPIK3R1 | |
| SCHEMBL5606978 | 0.90 | PIK3CG (0.51) | PIK3CGPIK3CDPIK3CBPIK3CAPIK3R1 | |
| SCHEMBL2328978 | 0.85 | PIK3CG (0.49) | PIK3CGPIK3CDPIK3CBPIK3CAPIK3R1 | |
| SCHEMBL5607107 | 0.84 | PIK3CD (0.43) | PIK3CGPIK3CDPIK3CBPIK3CAPIK3R1 | |
| SCHEMBL5607116 | 0.82 | PIK3CD (0.55) | PIK3CGPIK3CDPIK3CBPIK3CAPIK3R1 | |
| SCHEMBL7207017 | 0.82 | PIK3CG (0.53) | PIK3CGPIK3CDPIK3CBPIK3CAPIK3R1 | |
| SCHEMBL5606912 | 0.81 | PIK3CD (0.47) | PIK3CGPIK3CDPIK3CBPIK3CAPIK3R1 | |
| SCHEMBL5607754 | 0.81 | PIK3CD (0.48) | PIK3CGPIK3CDPIK3CBPIK3CAPIK3R1 | |
| SCHEMBL18391930 | 0.81 | PIK3CD (0.57) | PIK3CGPIK3CDPIK3CBPIK3CAPIK3R1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1750715-A1 | METHODS FOR TREATING MAST CELL DISORDERS | ICOS CORPORATION (US) | 2007-02-14 | — | — | EP | disclosed |
| WO-2005120511-A1 | METHODS FOR TREATING MAST CELL DISORDERS | ICOS CORPORATION (US) | 2005-12-22 | — | — | WO | disclosed |