Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 11/20 | 0.59 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.50 |
| ▸ | HTT | P42858 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5608016 | 0.94 | LCK (0.54) | LCKHTTALDH1A1LMNANPC1 | |
| SCHEMBL5607542 | 0.89 | LCK (0.71) | LCKCHRNA7 | |
| SCHEMBL771915 | 0.86 | LCK (0.82) | LCK | |
| SCHEMBL774344 | 0.84 | LCK (0.60) | LCKCHRNA7ALDH1A1LMNANPC1 | |
| SCHEMBL6604812 | 0.83 | LCK (0.83) | LCKCHRNA7HTTALDH1A1LMNA | |
| SCHEMBL5608233 | 0.81 | CHRNA7 (0.64) | LCKCHRNA7ALDH1A1MAPT | |
| SCHEMBL774952 | 0.80 | LCK (0.76) | LCK | |
| SCHEMBL5607304 | 0.79 | LCK (0.57) | LCKCHRNA7HTTALDH1A1LMNA | |
| SCHEMBL774457 | 0.79 | LCK (0.72) | LCKCHRNA7HTTALDH1A1LMNA | |
| SCHEMBL5607983 | 0.77 | CHRNA7 (0.60) | LCKCHRNA7HTTALDH1A1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1758564-A2 | SYNERGISTIC METHODS AND COMPOSITIONS FOR TREATING CANCER | Brystol-Myers Squibb Company (US) | 2007-03-07 | — | — | EP | claimed |
| WO-2005094376-A2 | SYNERGISTIC METHODS AND COMPOSITIONS FOR TREATING CANCER | BRISTOL-MYERS SQUIBB COMPANY (US) | 2005-10-13 | — | — | WO | claimed |
| EP-1758564-A2 | SYNERGISTIC METHODS AND COMPOSITIONS FOR TREATING CANCER | Brystol-Myers Squibb Company (US) | 2007-03-07 | — | — | EP | disclosed |
| WO-2005094376-A2 | SYNERGISTIC METHODS AND COMPOSITIONS FOR TREATING CANCER | BRISTOL-MYERS SQUIBB COMPANY (US) | 2005-10-13 | — | — | WO | disclosed |