Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 1/20 | 0.64 |
| ▸ | LCK | P06239 | 12/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.57 |
| ▸ | MAPT | P10636 | 2/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | CLK1 | P49759 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5607542 | 0.89 | LCK (0.71) | CHRNA7LCK | |
| SCHEMBL775096 | 0.87 | LCK (0.84) | CHRNA7LCKKDM4EALDH1A1MAPT | |
| SCHEMBL1539906 | 0.84 | LCK (0.60) | CHRNA7LCKKDM4EALDH1A1MAPT | |
| SCHEMBL6604812 | 0.83 | LCK (0.83) | CHRNA7LCKALDH1A1 | |
| SCHEMBL5607299 | 0.81 | LCK (0.59) | CHRNA7LCKALDH1A1MAPT | |
| SCHEMBL6834770 | 0.79 | CHRNA7 (0.49) | CHRNA7LCKKDM4EALDH1A1MAPT | |
| SCHEMBL5607304 | 0.79 | LCK (0.57) | CHRNA7LCKALDH1A1 | |
| SCHEMBL774457 | 0.79 | LCK (0.72) | CHRNA7LCKKDM4EALDH1A1MAPT | |
| SCHEMBL772863 | 0.77 | LCK (0.71) | CHRNA7LCKKDM4EALDH1A1MAPT | |
| SCHEMBL5607983 | 0.77 | CHRNA7 (0.60) | CHRNA7LCKKDM4EALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1758564-A2 | SYNERGISTIC METHODS AND COMPOSITIONS FOR TREATING CANCER | Brystol-Myers Squibb Company (US) | 2007-03-07 | — | — | EP | disclosed |
| WO-2005094376-A2 | SYNERGISTIC METHODS AND COMPOSITIONS FOR TREATING CANCER | BRISTOL-MYERS SQUIBB COMPANY (US) | 2005-10-13 | — | — | WO | disclosed |