Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Diphenylmethane. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CALM1 | P0DP23 | 1/20 | 0.75 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.62 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.62 |
| ▸ | LMNA | P02545 | 1/20 | 0.62 |
| ▸ | CES2 | O00748 | 1/20 | 0.57 |
| ▸ | CES1 | P23141 | 1/20 | 0.57 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.54 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.54 |
| ▸ | HNF4A | P41235 | 1/20 | 0.54 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.52 |
| ▸ | IDH1 | O75874 | 1/20 | 0.52 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | BCL2 | P10415 | 1/20 | 0.50 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.50 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.50 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Diphenylmethane SCHEMBL8658678 | 1.00 | CALM1 (0.75) | CALM1PLA2G10PLA2G2ALMNACES2 | |
| Diphenylmethane SCHEMBL29127396 | 1.00 | CALM1 (0.75) | CALM1PLA2G10PLA2G2ALMNACES2 | |
| Diphenylmethane SCHEMBL10394702 | 0.90 | CALM1 (0.92) | CALM1PLA2G10PLA2G2ALMNACES2 | |
| Diphenylmethane SCHEMBL10451543 | 0.88 | PLA2G10 (0.71) | CALM1PLA2G10PLA2G2ALMNACES2 | |
| Diphenylmethane SCHEMBL18604552 | 0.88 | PLA2G10 (0.71) | CALM1PLA2G10PLA2G2ALMNACES2 | |
| Diphenylmethane SCHEMBL8743340 | 0.88 | PLA2G10 (0.71) | CALM1PLA2G10PLA2G2ALMNACES2 | |
| Diphenylmethane SCHEMBL28144267 | 0.88 | PLA2G10 (0.71) | CALM1PLA2G10PLA2G2ALMNACES2 | |
| Diphenylmethane SCHEMBL4361124 | 0.87 | CALM1 (1.00) | CALM1PLA2G10PLA2G2ALMNAIDH1 | |
| Diphenylmethane SCHEMBL3792579 | 0.87 | CALM1 (1.00) | CALM1PLA2G10PLA2G2ALMNAIDH1 | |
| Diphenylmethane SCHEMBL14763944 | 0.87 | CALM1 (1.00) | CALM1PLA2G10PLA2G2ALMNAIDH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1272587-B1 | IMPACT-RESISTANT EPOXY RESIN COMPOSITIONS | HENKEL KGAA (DE) | 2004-05-19 | — | — | EP | claimed |
| EP-0962459-B1 | DIACETAL COMPOSITION, PROCESS FOR THE PREPARATION OF THE SAME, NUCLEATING AGENT FOR POLYOLEFINS CONTAINING THE SAME, POLYOLEFIN RESIN COMPOSITIONS, AND MOLDINGS | NEW JAPAN CHEM CO LTD (JP) | 2003-10-01 | — | — | EP | claimed |
| EP-1272587-A1 | IMPACT-RESISTANT EPOXY RESIN COMPOSITIONS | Henkel Kommanditgesellschaft auf Aktien (DE) | 2003-01-08 | — | — | EP | claimed |
| WO-2001094492-A1 | IMPACT-RESISTANT EPOXY RESIN COMPOSITIONS | HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (DE) | 2001-12-13 | — | — | WO | claimed |
| EP-1456321-B1 | MULTI-PHASE STRUCTURAL ADHESIVES | HENKEL KGAA (DE) | 2007-04-18 | — | — | EP | disclosed |
| EP-1123348-B1 | IMPACT-RESISTANT EPOXIDE RESIN COMPOSITIONS | HENKEL TEROSON GMBH (DE) | 2005-12-28 | — | — | EP | disclosed |
| EP-1272587-B1 | IMPACT-RESISTANT EPOXY RESIN COMPOSITIONS | HENKEL KGAA (DE) | 2004-05-19 | — | — | EP | disclosed |
| EP-1272587-A1 | IMPACT-RESISTANT EPOXY RESIN COMPOSITIONS | Henkel Kommanditgesellschaft auf Aktien (DE) | 2003-01-08 | — | — | EP | disclosed |
| WO-2001094492-A1 | IMPACT-RESISTANT EPOXY RESIN COMPOSITIONS | HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (DE) | 2001-12-13 | — | — | WO | disclosed |
| EP-1123348-A2 | IMPACT-RESISTANT EPOXIDE RESIN COMPOSITIONS | Henkel Teroson GmbH (DE) | 2001-08-16 | — | — | EP | disclosed |
| WO-2000020483-A2 | IMPACT-RESISTANT EPOXIDE RESIN COMPOSITIONS | HENKEL TEROSON GMBH (DE) | 2000-04-13 | — | — | WO | disclosed |