Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 10/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 6/20 | 0.37 |
| ▸ | PIK3CG | P48736 | 6/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 5/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.37 |
| ▸ | PIK3R1 | P27986 | 4/20 | 0.37 |
| ▸ | PIK3CB | P42338 | 4/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.37 |
| ▸ | HDAC7 | Q8WUI4 | 4/20 | 0.37 |
| ▸ | HDAC5 | Q9UQL6 | 4/20 | 0.37 |
| ▸ | HDAC11 | Q96DB2 | 4/20 | 0.37 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.37 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.37 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5606975 | 0.91 | PIK3CD (0.44) | PIK3CDALDH1A1HIF1AKDM4EGAA | |
| SCHEMBL5607959 | 0.85 | PIK3CD (0.39) | PIK3CDALDH1A1PIK3CAPIK3CGPIK3R1 | |
| SCHEMBL357085 | 0.83 | PIK3CD (0.55) | PIK3CDPIK3CAPIK3CGPIK3R1PIK3CB | |
| SCHEMBL5606978 | 0.82 | PIK3CG (0.51) | PIK3CDPIK3CAPIK3CGPIK3R1PIK3CB | |
| SCHEMBL14993340 | 0.82 | PIK3CD (0.51) | PIK3CDPIK3CAPIK3CGPIK3R1PIK3CB | |
| SCHEMBL5606808 | 0.82 | PIK3CD (0.51) | PIK3CDPIK3CAPIK3CGPIK3R1PIK3CB | |
| SCHEMBL5607766 | 0.80 | PIK3CD (0.51) | PIK3CDALDH1A1PIK3CAPIK3CGPIK3R1 | |
| SCHEMBL5607475 | 0.80 | ALDH1A1 (0.50) | PIK3CDALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL2432095 | 0.78 | PIK3CD (0.41) | PIK3CDALDH1A1PIK3CAPIK3CGPIK3R1 | |
| SCHEMBL2328978 | 0.78 | PIK3CG (0.49) | PIK3CDPIK3CAPIK3CGPIK3R1PIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1750715-A1 | METHODS FOR TREATING MAST CELL DISORDERS | ICOS CORPORATION (US) | 2007-02-14 | — | — | EP | claimed |
| WO-2005120511-A1 | METHODS FOR TREATING MAST CELL DISORDERS | ICOS CORPORATION (US) | 2005-12-22 | — | — | WO | claimed |