Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 14/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5607804 | 0.84 | LCK (0.71) | LCKALDH1A1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL5607823 | 0.83 | LCK (0.58) | LCKMAPTNPC1RAB9A | |
| SCHEMBL7635041 | 0.83 | LCK (0.59) | LCK | |
| SCHEMBL3720281 | 0.80 | LCK (0.61) | LCKALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL774712 | 0.79 | LCK (0.61) | LCKKDM4EALDH1A1KMT2A | |
| SCHEMBL5608004 | 0.79 | LCK (0.69) | LCKALDH1A1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL772502 | 0.78 | LCK (0.66) | LCKKDM4EALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL774071 | 0.77 | LCK (0.72) | LCKKDM4EALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL1539957 | 0.76 | LCK (0.64) | LCKALDH1A1SMN1; SMN2KMT2AMAPT | |
| SCHEMBL773079 | 0.75 | LCK (0.64) | LCKALDH1A1SMN1; SMN2NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1758564-A2 | SYNERGISTIC METHODS AND COMPOSITIONS FOR TREATING CANCER | Brystol-Myers Squibb Company (US) | 2007-03-07 | — | — | EP | claimed |
| WO-2005094376-A2 | SYNERGISTIC METHODS AND COMPOSITIONS FOR TREATING CANCER | BRISTOL-MYERS SQUIBB COMPANY (US) | 2005-10-13 | — | — | WO | claimed |
| EP-1169038-A4 | CYCLIC PROTEIN TYROSINE KINASE INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2004-10-13 | — | — | EP | claimed |
| EP-1169038-A1 | CYCLIC PROTEIN TYROSINE KINASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2002-01-09 | — | — | EP | claimed |
| WO-2000062778-A1 | CYCLIC PROTEIN TYROSINE KINASE INHIBITORS | BRISTOL-MYERS SQUIBB CO. (US) | 2000-10-26 | — | — | WO | claimed |