Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 1/20 | 0.37 |
| ▸ | EIF2AK3 | Q9NZJ5 | 1/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.37 |
| ▸ | CDC25B | P30305 | 2/20 | 0.37 |
| ▸ | CDC25A | P30304 | 1/20 | 0.37 |
| ▸ | CDC25C | P30307 | 1/20 | 0.37 |
| ▸ | CSF1R | P07333 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 4/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | UBE2N | P61088 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1994463 | 0.87 | MEN1 (0.42) | PDE4BCDC25BCDC25ACDC25CALDH1A1 | |
| SCHEMBL1994381 | 0.86 | PDE4B (0.42) | PDE4BCDC25BCDC25ACDC25CMAPT | |
| SCHEMBL1993863 | 0.83 | PDE4B (0.46) | PDE4BCSF1RMAPTKDM4EALDH1A1 | |
| SCHEMBL5608178 | 0.81 | PDE4B (0.35) | BRAFEIF2AK3PDE4BMAPTKDM4E | |
| SCHEMBL1996419 | 0.79 | KMT2A (0.40) | PDE4BMAPTKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL1995355 | 0.78 | PDE4B (0.41) | PDE4BMAPTKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL5263166 | 0.78 | PDE4B (0.42) | PDE4BMAPTKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL1994578 | 0.78 | PDE4B (0.40) | PDE4BMAPTKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL1997568 | 0.77 | PDE4B (0.38) | PDE4BMAPTKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL1996261 | 0.77 | PDE4B (0.40) | PDE4BMAPTKDM4EALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1758869-A1 | PYRIDAZIN-3(2H)-ONE DERIVATIVES AND THEIR USE AS PDE4 INHIBITORS | Almirall Prodesfarma, S.A. (ES) | 2007-03-07 | — | — | EP | claimed |
| WO-2005123692-A1 | PYRIDAZIN-3(2H)-ONE DERIVATIVES AND THEIR USE AS PDE4 INHIBITORS | LABORATORIOS ALMIRALL, S.A. (ES) | 2005-12-29 | — | — | WO | claimed |