Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 3/20 | 0.35 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.33 |
| ▸ | BRAF | P15056 | 2/20 | 0.32 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | PDE4A | P27815 | 1/20 | 0.31 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.31 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.31 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.31 |
| ▸ | EIF2AK3 | Q9NZJ5 | 1/20 | 0.31 |
| ▸ | NAMPT | P43490 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | UBE2N | P61088 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1995355 | 0.84 | PDE4B (0.41) | PDE4BTRPV1MAPTPDE4APDE4C | |
| SCHEMBL1997221 | 0.83 | PDE4B (0.42) | PDE4BMAPTKDM4EMEN1ALDH1A1 | |
| SCHEMBL1997288 | 0.82 | PDE4B (0.46) | PDE4BLRRK2MAPTPDE4APDE4C | |
| SCHEMBL5607932 | 0.82 | TRPV1 (0.30) | TRPV1 | |
| SCHEMBL5607919 | 0.81 | BRAF (0.37) | PDE4BBRAFMAPTEIF2AK3KDM4E | |
| SCHEMBL1994381 | 0.81 | PDE4B (0.42) | PDE4BMAPTPDE4APDE4CPDE4D | |
| SCHEMBL1993517 | 0.80 | PDE4B (0.46) | PDE4BTRPV1MAPTNAMPTMEN1 | |
| SCHEMBL1992771 | 0.79 | PDE4B (0.39) | PDE4BTRPV1MAPTKDM4EMEN1 | |
| SCHEMBL1997026 | 0.78 | PDE4B (0.41) | PDE4BPDE4APDE4CPDE4DALDH1A1 | |
| SCHEMBL1993863 | 0.78 | PDE4B (0.46) | PDE4BMAPTPDE4APDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1758869-A1 | PYRIDAZIN-3(2H)-ONE DERIVATIVES AND THEIR USE AS PDE4 INHIBITORS | Almirall Prodesfarma, S.A. (ES) | 2007-03-07 | — | — | EP | claimed |
| WO-2005123692-A1 | PYRIDAZIN-3(2H)-ONE DERIVATIVES AND THEIR USE AS PDE4 INHIBITORS | LABORATORIOS ALMIRALL, S.A. (ES) | 2005-12-29 | — | — | WO | claimed |