Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | RAB9A | P51151 | 4/20 | 0.39 |
| ▸ | NPC1 | O15118 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | PTPRC | P08575 | 2/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | APAF1 | O14727 | 1/20 | 0.38 |
| ▸ | TDP2 | O95551 | 1/20 | 0.38 |
| ▸ | NSD2 | O96028 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5819648 | 0.76 | ESR1 (0.43) | PTPRCMAPTPDPK1CA9CA12 | |
| SCHEMBL5817820 | 0.76 | CES1 (0.48) | MEN1KMT2ALMNAS100A4MAPT | |
| SCHEMBL9037526 | 0.68 | RET (0.53) | ALDH1A1RAB9ANPC1SMN1; SMN2TDP1 | |
| SCHEMBL2970333 | 0.66 | NPC1 (0.50) | ALDH1A1RAB9ANPC1SMN1; SMN2TDP1 | |
| SCHEMBL7223095 | 0.66 | NPC1 (0.50) | ALDH1A1RAB9ANPC1SMN1; SMN2TDP1 | |
| SCHEMBL1853800 | 0.65 | TGM2 (0.60) | ALDH1A1RETFLT3ALKPDPK1 | |
| SCHEMBL2529842 | 0.65 | NPC1 (0.41) | ALDH1A1RAB9ANPC1SMN1; SMN2TDP1 | |
| SCHEMBL5822740 | 0.64 | MAOA (0.41) | ALDH1A1RAB9ANPC1SMN1; SMN2HTT | |
| SCHEMBL4426047 | 0.64 | TGM2 (0.38) | KDM4ECA9PARP1 | |
| SCHEMBL2062046 | 0.63 | RET (0.41) | ALDH1A1RAB9ANPC1SMN1; SMN2TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1797042-A1 | INDOZOLONE DERIVATIVES AS 11B-HSD1 INHIBITORS | F.HOFFMANN-LA ROCHE AG (CH) | 2007-06-20 | — | — | EP | disclosed |
| WO-2006034804-A1 | INDOZOLONE DERIVATIVES AS 11B-HSD1 INHIBITORS | F.HOFFMANN-LA ROCHE AG (CH) | 2006-04-06 | — | — | WO | disclosed |