Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 5/20 | 0.46 |
| ▸ | GSPT1 | P15170 | 1/20 | 0.42 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.42 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.42 |
| ▸ | HTR6 | P50406 | 4/20 | 0.42 |
| ▸ | HTR1A | P08908 | 1/20 | 0.42 |
| ▸ | HTR1D | P28221 | 1/20 | 0.42 |
| ▸ | HTR1B | P28222 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | HTR2C | P28335 | 1/20 | 0.42 |
| ▸ | HTR1F | P30939 | 1/20 | 0.42 |
| ▸ | HTR7 | P34969 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.38 |
| ▸ | CCR4 | P51679 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3917157 | 0.85 | GSPT1 (0.42) | BRD4GSPT1DDB1CRBNHTR6 | |
| SCHEMBL5608331 | 0.83 | GSPT1 (0.48) | BRD4GSPT1DDB1CRBNHTR6 | |
| SCHEMBL5617460 | 0.81 | PFKFB3 (0.41) | BRD4HTR6ALDH1A1LMNAMEN1 | |
| SCHEMBL1802901 | 0.81 | BRD4 (0.41) | BRD4GSPT1DDB1CRBNHTR6 | |
| SCHEMBL5617634 | 0.79 | MEN1 (0.49) | HTR6HTR2AHTR2CALDH1A1LMNA | |
| SCHEMBL3906958 | 0.73 | LMNA (0.46) | BRD4GSPT1DDB1CRBNHTR6 | |
| SCHEMBL618067 | 0.73 | BRD4 (0.56) | BRD4GSPT1DDB1CRBNHTR6 | |
| SCHEMBL5609111 | 0.72 | TP53 (0.46) | BRD4HTR6LMNAKMT2ATHRB | |
| SCHEMBL3903016 | 0.71 | NR1I2 (0.48) | BRD4GSPT1DDB1CRBNHIF1A | |
| SCHEMBL1811055 | 0.71 | GSPT1 (0.45) | BRD4GSPT1DDB1CRBNHTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1797042-A1 | INDOZOLONE DERIVATIVES AS 11B-HSD1 INHIBITORS | F.HOFFMANN-LA ROCHE AG (CH) | 2007-06-20 | — | — | EP | disclosed |
| WO-2006034804-A1 | INDOZOLONE DERIVATIVES AS 11B-HSD1 INHIBITORS | F.HOFFMANN-LA ROCHE AG (CH) | 2006-04-06 | — | — | WO | disclosed |