Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | TACR1 | P25103 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 5/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | SSTR3 | P32745 | 1/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.35 |
| ▸ | MC4R | P32245 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7500962 | 0.90 | CYP3A4 (0.43) | HTR2ATACR1CYP2D6SLC6A2SLC6A4 | |
| SCHEMBL4604214 | 0.90 | TACR1 (0.44) | TACR1CYP2D6TSHRMEN1KMT2A | |
| SCHEMBL27890446 | 0.80 | CYP3A4 (0.46) | MEN1KMT2ACYP3A4KDM4EMAPT | |
| SCHEMBL27800697 | 0.77 | CYP3A4 (0.43) | TSHRMEN1KMT2ACYP3A4KDM4E | |
| SCHEMBL11039283 | 0.77 | CYP3A4 (0.43) | MEN1KMT2ACYP3A4KDM4EMAPT | |
| SCHEMBL27893441 | 0.75 | KDM4E (0.42) | SLC6A4TSHRMEN1KMT2ACYP3A4 | |
| Bromide SCHEMBL11037477 | 0.75 | CYP3A4 (0.42) | MEN1KMT2ACYP3A4KDM4EMAPT | |
| SCHEMBL15928065 | 0.75 | IDO1 (0.39) | HTR2ATACR1CYP2D6TSHRMEN1 | |
| SCHEMBL20787990 | 0.74 | TACR1 (0.45) | TACR1CYP2D6SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL8881428 | 0.72 | MEN1 (0.38) | HTR2ATACR1CYP2D6SLC6A2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1805165-A1 | 1-(HETERO)ARYL-3-AMINO-PYROLLIDINE DERIVATIVES FOR USE AS MGLUR3 RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 2007-07-11 | — | — | EP | disclosed |
| WO-2006044454-A1 | 1-(HETERO)ARYL-3-AMINO-PYROLLIDINE DERIVATIVES FOR USE AS MGLUR3 RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 2006-04-27 | — | — | WO | disclosed |