SCHEMBL5609240

SCHEMBL5609240

CCOC(=O)c1cc(C)c(C)cc1C(=O)c1ccccc1

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 3/20 0.58
ALDH1A1 P00352 6/20 0.50
HSD17B10 Q99714 2/20 0.50
SMN1; SMN2 Q16637 6/20 0.49
RAB9A P51151 5/20 0.49
NPC1 O15118 4/20 0.49
POLB P06746 2/20 0.49
NFKB1 P19838 2/20 0.49
NFKB2 Q00653 2/20 0.49
RELA Q04206 2/20 0.49
GLA P06280 1/20 0.49
NPSR1 Q6W5P4 1/20 0.49
HPGD P15428 4/20 0.49
MAPT P10636 3/20 0.47
KDM4E B2RXH2 1/20 0.47
CASP3 P42574 1/20 0.47
SENP8 Q96LD8 1/20 0.47
SENP7 Q9BQF6 1/20 0.47
SENP6 Q9GZR1 1/20 0.47
HTT P42858 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13305618 0.85 TSHR (0.51) TSHRALDH1A1HSD17B10SMN1; SMN2RAB9A
SCHEMBL13178323 0.85 TSHR (0.51) TSHRALDH1A1HSD17B10SMN1; SMN2RAB9A
SCHEMBL29619268 0.85 TSHR (0.75) TSHRALDH1A1HSD17B10SMN1; SMN2RAB9A
SCHEMBL195278 0.85 TSHR (0.75) TSHRALDH1A1HSD17B10SMN1; SMN2RAB9A
SCHEMBL4734723 0.84 TSHR (0.54) TSHRALDH1A1HSD17B10SMN1; SMN2RAB9A
SCHEMBL4733091 0.83 TSHR (0.53) TSHRALDH1A1HSD17B10SMN1; SMN2RAB9A
SCHEMBL13301724 0.83 CA12 (0.53) TSHRALDH1A1SMN1; SMN2RAB9ANPC1
SCHEMBL4625850 0.82 TSHR (0.61) TSHRALDH1A1HSD17B10SMN1; SMN2NPC1
SCHEMBL16108187 0.82 TSHR (0.56) TSHRALDH1A1SMN1; SMN2NPC1POLB
SCHEMBL14037067 0.82 ALDH1A1 (0.57) TSHRALDH1A1SMN1; SMN2POLBNPSR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2495260-B2 MANUFACTURING METHOD FOR PROPYLENE POLYMER JAPAN POLYPROPYLENE CORP (JP) 2018-10-24 EP disclosed
US-8957166-B2 Method for producing propylene-based polymer JAPAN POLYPROPYLENE CORPORATION (JP) 2015-02-17 US disclosed
EP-2495260-B1 MANUFACTURING METHOD FOR PROPYLENE POLYMER JAPAN POLYPROPYLENE CORP (JP) 2014-06-04 EP disclosed
US-20120302716-A1 METHOD FOR PRODUCING PROPYLENE-BASED POLYMER JAPAN POLYPROPYLENE CORPORATION (JP) 2012-11-29 US disclosed
EP-2495260-A1 MANUFACTURING METHOD FOR PROPYLENE POLYMER Japan Polypropylene Corporation (JP) 2012-09-05 EP disclosed
US-7276463-B2 Polymerization catalyst for α-olefins and process for production of α-olefin polymers therewith JAPAN POLYPROPYLENE CORPORATION (JP) 2007-10-02 US disclosed
US-20060068984-A1 Plymerization catalyst for a-olefins and process for production of alpha-olefin polymers therewith JAPAN POLYCHEM CORPORATION (JP) 2006-03-30 US disclosed
EP-1548035-A1 CATALYST FOR POLYMERIZING a-OLEFIN AND PRODUCTION METHOD OF a-OLEFIN POLYMER USING THE SAME Japan Polypropylene Corporation (JP) 2005-06-29 EP disclosed
EP-1160263-A1 PROCESS FOR PRODUCING ALPHA-OLEFIN POLYMER Japan Polychem Corporation (JP) 2001-12-05 EP disclosed
EP-0773235-B1 Polymerization of alpha-olefins MITSUBISHI CHEM CORP (JP) 1999-05-26 EP disclosed
EP-0773235-A1 Polymerization of alpha-olefins MITSUBISHI CHEMICAL CORPORATION (JP) 1997-05-14 EP disclosed