Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 3/20 | 0.53 |
| ▸ | NR1H2 | P55055 | 3/20 | 0.53 |
| ▸ | NR1H3 | Q13133 | 3/20 | 0.53 |
| ▸ | PDE10A | Q9Y233 | 12/20 | 0.38 |
| ▸ | RIPK3 | Q9Y572 | 1/20 | 0.38 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.36 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.35 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.35 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.35 |
| ▸ | RET | P07949 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5610648 | 0.85 | RXRA (0.53) | RXRANR1H2NR1H3RIPK3GRIN1 | |
| SCHEMBL2389451 | 0.84 | RXRA (0.54) | RXRANR1H2NR1H3RIPK3AGTR1 | |
| SCHEMBL2391493 | 0.81 | RXRA (0.57) | RXRANR1H2NR1H3RIPK3AGTR1 | |
| SCHEMBL2388058 | 0.81 | RXRA (0.51) | RXRANR1H2NR1H3RIPK3AGTR1 | |
| SCHEMBL2388279 | 0.80 | RXRA (0.48) | RXRANR1H2NR1H3RIPK3AGTR1 | |
| SCHEMBL2386535 | 0.80 | RXRA (0.48) | RXRANR1H2NR1H3RIPK3RET | |
| SCHEMBL5615380 | 0.78 | RXRA (0.58) | RXRANR1H2NR1H3PDE10ARET | |
| SCHEMBL5597884 | 0.78 | RXRA (0.57) | RXRANR1H2NR1H3PDE10AAGTR1 | |
| SCHEMBL5816750 | 0.77 | RXRA (0.61) | RXRANR1H2NR1H3RIPK3 | |
| SCHEMBL5793671 | 0.76 | RXRA (0.61) | RXRANR1H2NR1H3RIPK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1773337-A2 | MODULATORS OF NUCLEAR RECEPTORS | Exelixis, Inc. (US) | 2007-04-18 | — | — | EP | claimed |
| WO-2006025979-A2 | MODULATORS OF NUCLEAR RECEPTORS | EXELIXIS, INC. (US) | 2006-03-09 | — | — | WO | claimed |