Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 2/20 | 0.42 |
| ▸ | THRA | P10827 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.41 |
| ▸ | MEN1 | O00255 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | EPHB4 | P54760 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | IGF1R | P08069 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | SYK | P43405 | 1/20 | 0.37 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.37 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.37 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5592585 | 0.92 | MEN1 (0.47) | KMT2AMEN1LMNAEPHB4MAPT | |
| SCHEMBL166253 | 0.90 | EPHB4 (0.42) | THRBTHRAKMT2AMEN1LMNA | |
| SCHEMBL12029094 | 0.87 | THRA (0.41) | THRBTHRAEPHB4TP53SYK | |
| SCHEMBL165575 | 0.84 | EPHB4 (0.46) | KMT2AMEN1ALDH1A1LMNAEPHB4 | |
| SCHEMBL5592945 | 0.84 | MAPT (0.50) | KMT2AMEN1LMNAEPHB4MAPT | |
| Hydrochloric Acid SCHEMBL168314 | 0.84 | EPHB4 (0.45) | KMT2AMEN1ALDH1A1LMNAEPHB4 | |
| SCHEMBL5959796 | 0.83 | MEN1 (0.50) | KMT2AMEN1LMNAEPHB4MAPT | |
| SCHEMBL165500 | 0.83 | EPHB4 (0.41) | KMT2AMEN1LMNAEPHB4MAPT | |
| SCHEMBL5593101 | 0.83 | MAPT (0.43) | THRBTHRAKMT2AMEN1ALDH1A1 | |
| Ji-101 SCHEMBL5585996 | 0.82 | EPHB4 (0.46) | THRBTHRAKMT2AMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1858879-A1 | 1,3-DIARYL SUBSTITUTED UREAS AS MODULATORS OF KINASE ACTIVITY | CGI Pharmaceuticals, Inc. (US) | 2007-11-28 | — | — | EP | disclosed |
| WO-2006076593-A1 | 1,3-DIARYL SUBSTITUTED UREAS AS MODULATORS OF KINASE ACTIVITY | CGI PHARMACEUTICALS, INC. (US) | 2006-07-20 | — | — | WO | disclosed |